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首页> 外文期刊>Neuron >Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain.
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Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain.

机译：预测疼痛和镇痛的价值：存在慢性疼痛时伏伏核对有害刺激的反应。

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摘要

We compared brain activations in response to acute noxious thermal stimuli in controls and chronic back pain (CBP) patients. Pain perception and related cortical activation patterns were similar in the two groups. However, nucleus accumbens (NAc) activity differentiated the groups at a very high accuracy, exhibiting phasic and tonic responses with distinct properties. Positive phasic NAc activations at stimulus onset and offset tracked stimulus salience and, in normal subjects, predicted reward (pain relief) magnitude at stimulus offset. In CBP, NAc activity correlated with different cortical circuitry from that of normals and phasic activity at stimulus offset was negative in polarity, suggesting that the acute pain relieves the ongoing back pain. The relieving effect was confirmed in a separate psychophysical study in CBP. Therefore, in contrast to somatosensory pathways, which reflect sensory properties of acute noxious stimuli, NAc activity in humans encodes its predicted value and anticipates its analgesic potential on chronic pain. VIDEO ABSTRACT:
机译：我们比较了对照组和慢性背痛（CBP）患者对急性有害热刺激的大脑激活。两组的疼痛知觉和相关的皮质激活模式相似。但是，伏伏核（NAc）活性以非常高的准确度区分了这些基团，表现出具有不同特性的相位和张力响应。在刺激发作和偏移时，正相NAc激活跟踪刺​​激的显着性，在正常受试者中，在刺激偏移时预测的奖励（疼痛缓解）幅度。在CBP中，NAc活性与正常大脑皮层回路的活动不同，刺激偏移时的相位活性极性相反，这表明急性疼痛减轻了正在进行的背痛。 CBP的另一项心理生理研究证实了其缓解作用。因此，与反映急性有害刺激的感觉特性的体感途径相反，人体内的NAc活性编码其预测值并预期其对慢性疼痛的镇痛潜力。视频摘要：

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