...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-cadherin trafficking.
【24h】

Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-cadherin trafficking.

机译：Rab GTPases依赖的内吞途径通过N-钙粘着蛋白运输调节神经元迁移和成熟。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although membrane trafficking pathways are involved in basic cellular functions, the evolutionally expanded number of their related family proteins suggests additional roles for membrane trafficking in higher organisms. Here, we show that several Rab-dependent trafficking pathways differentially participate in neuronal migration, an essential step for the formation of the mammalian-specific six-layered brain structure. In vivo electroporation-mediated suppression of Rab5 or dynamin to block endocytosis caused a severe neuronal migration defect in mouse cerebral cortex. Among many downstream endocytic pathways, suppression of Rab11-dependent recycling pathways exhibited a similar migration disorder, whereas inhibition of Rab7-dependent lysosomal degradation pathways affected only the final phase of neuronal migration and dendrite morphology. Inhibition of Rab5 or Rab11 perturbed the trafficking of N-cadherin, whose suppression also disturbed neuronal migration. Taken together, our findings reveal physiological roles of endocytic pathways, each of which has specific functions in distinct steps of neuronal migration and maturation during mammalian brain formation.
机译：尽管膜运输途径参与基本的细胞功能，但其相关家族蛋白的进化数目增加表明在高等生物中膜运输的附加作用。在这里，我们显示了几种依赖Rab的贩运途径差异地参与了神经元迁移，这是形成哺乳动物特异性六层脑结构的必要步骤。体内电穿孔介导的Rab5或动力蛋白的抑制以阻止内吞作用在小鼠大脑皮质中引起严重的神经元迁移缺陷。在许多下游内吞途径中，抑制Rab11依赖的回收途径表现出相似的迁移障碍，而抑制Rab7依赖的溶酶体降解途径仅影响神经元迁移和树突形态的最后阶段。抑制Rab5或Rab11扰乱了N-钙粘蛋白的运输，其抑制作用也干扰了神经元的迁移。综上所述，我们的发现揭示了内吞途径的生理作用，在哺乳动物脑形成过程中，每个途径在神经元迁移和成熟的不同步骤中都具有特定的功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号