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首页> 外文期刊>Neuron >Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord
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Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

机译：强啡肽作为抑制脊髓背角瘙痒的神经调节剂

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摘要

Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for minutes to hours. However, the neural basis for this effect is unclear, and the underlying neuromodulatory mechanisms are unknown. Previous studies revealed that Bhlhb5-/- mice, which lack a specific population of spinal inhibitory interneurons (B5-I neurons), develop pathological itch. Here we characterize B5-I neurons and show that they belong to a neurochemically distinct subset. We provide cause-and-effect evidence that B5-I neurons inhibit itch and show that dynorphin, which is released from B5-I neurons, is a key neuromodulator of pruritus. Finally, we show that B5-I neurons are innervated by menthol-, capsaicin-, and mustard oil-responsive sensory neurons and are required for the inhibition of itch by menthol. These findings provide a cellular basis for the inhibition of itch by chemical counterstimuli and suggest that kappa opioids may be a broadly effective therapy for pathological itch.
机译：薄荷醇和其他刺激物可减轻瘙痒，导致止痒状态持续数分钟至数小时。但是，这种作用的神经基础尚不清楚，潜在的神经调节机制尚不清楚。先前的研究表明，缺乏特定数量的脊髓抑制性中间神经元（B5-I神经元）的Bhlhb5-/-小鼠会发生病理性瘙痒。在这里，我们表征B5-I神经元，并表明它们属于神经化学上不同的子集。我们提供B5-I神经元抑制瘙痒的因果证据，并显示从B5-I神经元释放的强啡肽是瘙痒症的关键神经调节剂。最后，我们显示B5-I神经元受薄荷醇，辣椒素和芥子油响应的感觉神经元支配，并且是抑制薄荷醇止痒所必需的。这些发现为化学反刺激抑制瘙痒提供了细胞基础，并提示κ阿片类药物可能是病理性瘙痒的广泛有效疗法。

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