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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Ependymoma with 'granular cell' features: Report of two cases
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Ependymoma with 'granular cell' features: Report of two cases

机译：具有“粒细胞”特征的室间隔膜瘤：2例报告

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摘要

We report two cases of ependymoma which showed prominent "granular cell" changes of the cytoplasm. The patients were a 7-year-old boy with a tumor in the cerebellum (case 1) and a 70-year-old man with a tumor in the frontal lobe (case 2). The tumor of case 1 showed a histopathological appearance of ependymoma containing many focal aggregates of large polygonal cells in which the cytoplasm was stuffed with numerous eosinophilic granules. The tumor of case 2 predominantly showed the features of papillary ependymoma, and some tumor cells were swollen and contained similar eosinophilic granules. Intracytoplasmic granules in both tumors were immunoreactive for GFAP and ubiquitin, but not for epithelial membrane antigen, CD68 or mitochondria. Ultrastructurally, they were found as aggregates of membrane-bound, electron-dense, globular structures. Karyotypic analysis of the tumor in case 1 demonstrated 2, 11 and 12 trisomies. Intracytoplasmic eosinophilic granules occasionally occur in astrocytic and oligodendroglial neoplasms, but an appearance of similar granules is very rare in ependymoma. The two cases presented here may represent a new histopathological variant of ependymoma, and the term "granular cell ependymoma" is appropriate for them.
机译：我们报告了两例室管膜瘤，它们显示出明显的细胞质“粒细胞”变化。患者是一个7岁的小男孩患有肿瘤的男孩（病例1）和一个70岁的额叶患有肿瘤的男孩（病例2）。病例1的肿瘤显示出室管膜瘤的组织病理学外观，其中包含许多大型多角形细胞的局灶性聚集体，其中细胞质充满了许多嗜酸性粒细胞。病例2的肿瘤主要表现为乳头状室间隔膜瘤的特征，一些肿瘤细胞肿胀并含有相似的嗜酸性颗粒。两种肿瘤的胞浆内颗粒对GFAP和泛素均具有免疫反应性，但对上皮膜抗原，CD68或线粒体则无免疫反应。在超微结构中，它们被发现是膜结合的，电子致密的球状结构的聚集体。病例1的肿瘤的核型分析显示2、11和12三体性。星形胶质细胞瘤和少突胶质细胞瘤中偶尔会出现胞浆内嗜酸性粒细胞，但在室间隔膜瘤中很少出现类似的颗粒。这里介绍的两个案例可能代表了室管膜瘤的一种新的组织病理学变异，术语“颗粒细胞室管膜瘤”适用于它们。

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