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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >An autopsy case of lymphomatosis cerebri showing pathological changes of intravascular large B-cell lymphoma in visceral organs.
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An autopsy case of lymphomatosis cerebri showing pathological changes of intravascular large B-cell lymphoma in visceral organs.

机译：脑部淋巴瘤病的尸检病例显示内脏器官中血管内大B细胞淋巴瘤的病理变化。

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We describe the case of a 61-year-old man presenting with subacute encephalopathy. The clinical manifestations included progressive dementia and pyramidal and extrapyramidal tract signs. Brain CT scan and MRI showed diffuse bilateral white matter changes in the cerebral hemispheres, basal ganglia, thalamus and brainstem. No contrast-enhanced lesion was observed. Peripheral blood studies, CSF analysis, and brain and muscle biopsies were nonspecific and failed to reveal diagnostic evidence of any specific disease. The patient was diagnosed with and treated for a cerebral demyelinating disorder. Post mortem examination showed diffuse infiltration of lymphoma cells without mass lesions in the extensive cerebral white and gray matter with minimal intravascular patterns, particularly in the perivascular and periventricular spaces. These findings were consistent with lymphomatosis cerebri (LC). In other visceral organs such as the lungs, liver, kidneys and adrenal glands, blood vessels were plugged by numerous neoplastic cells which were morphologically and immunohistochemically similar to those observed in the CNS, consistent with intravascular malignant lymphoma (IVL). To our knowledge, this is the first autopsy report showing the coexistence of LC and IVL. This case suggests a possible link between LC and IVL.
机译：我们描述了一个患有亚急性脑病的61岁男子的病例。临床表现包括进行性痴呆以及锥体束和锥体束外征象。脑部CT和MRI显示大脑半球，基底神经节，丘脑和脑干弥漫性双侧白质改变。没有观察到造影剂增强的病变。外周血研究，CSF分析以及脑和肌肉活组织检查是非特异性的，未能揭示任何特定疾病的诊断证据。该患者被诊断患有脑脱髓鞘疾病并已接受治疗。验后检查显示，在广泛的脑白和灰质中，淋巴瘤细胞弥漫性浸润，没有肿块，血管内形态极少，尤其是在血管周围和脑室周围。这些发现与脑淋巴瘤病（LC）一致。在其他内脏器官，例如肺，肝，肾和肾上腺中，血管被许多肿瘤细胞堵塞，这些细胞在形态和免疫组织化学上与在CNS中观察到的相似，与血管内恶性淋巴瘤（IVL）一致。就我们所知，这是显示LC和IVL并存的第一份尸检报告。这种情况表明LC和IVL之间可能存在联系。

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