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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Recurrent epileptic seizures with multifocal brain MRI lesions after paternal lymphocyte immunization: a causal relationship to multiple sclerosis?
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Recurrent epileptic seizures with multifocal brain MRI lesions after paternal lymphocyte immunization: a causal relationship to multiple sclerosis?

机译：父亲免疫接种后复发性癫痫发作伴多灶性脑MRI病变：与多发性硬化症有因果关系吗？

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摘要

Paternal lymphocyte immunization (PLI) is a widely used treatment for alloimmune-mediated recurrent spontaneous abortion (RSA) with rare adverse effects reported.1 We report a case in which the patient suffered from epilepsy with multifocal recurrent brain lesions shortly after PLI, and was controlled well by antiepileptic drugs and steroids. We diagnosed this case as multiple sclerosis (MS) which may be a rare side effect associated with PLI. A 35-year-old woman with RSA received a standard course (four times) of PLI treatment. At the end of treatment, she had a cluster of partial seizures and secondarily generalized seizures with sharp waves on both sides of the fronto-temporal areas on EEG. General physical and neurological examinations in interictal periods, ECG and CSF were normal. The patient showed no sign of preceding infection, fever, headache or meningism. Brain MRI showed multifocal T2-hyperintensity and Tl-hypointensity lesions in nodular shapes with enhancement in cortical and periven-tricular areas, mainly on the left side of the parietal lobe. She was treated with Lamotrigine 75 mg/day under presumptive diagnosis of a brain lesion and symptomatic epilepsy
机译：父本淋巴细胞免疫（PLI）是用于同种免疫介导的反复自然流产（RSA）的一种广泛使用的疗法，据报道罕见的不良反应。1我们报道了一例患者，该患者在PLI后不久就患有多灶性复发性脑病变的癫痫病。由抗癫痫药和类固醇很好地控制。我们将这种情况诊断为多发性硬化症（MS），这可能是与PLI相关的罕见副作用。一名患有RSA的35岁女性接受了PLI治疗的标准疗程（四次）。在治疗结束时，她在脑电图的额颞区两侧均出现一连串的部分性癫痫发作和第二次广泛性癫痫发作。发作期一般身体和神经系统检查，心电图和脑脊液均正常。患者未显示先前感染，发烧，头痛或脑膜炎的迹象。脑部MRI显示呈结节状的多灶性T2高血压和T1低血压病灶，主要在顶叶左侧的皮质和室周区域增强。根据推定诊断为脑部病变和症状性癫痫病，她接受拉莫三嗪75 mg / day的治疗

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