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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Two cases of atypical meningioma with pulmonary metastases: A comparative cytogenetic analysis of chromosomes 1p and 22 and a review of the literature
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Two cases of atypical meningioma with pulmonary metastases: A comparative cytogenetic analysis of chromosomes 1p and 22 and a review of the literature

机译：两例具有肺转移的非典型脑膜瘤病例：1p和22号染色体的比较细胞遗传学分析和文献综述

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摘要

We present two cases of atypical meningioma WHO grade II with a history of multiple local recurrences and late pulmonary metastases. Comparative cytogenetic analyses on 1p and 22q confirmed clonal origin of the primary intracranial meningiomas and the pulmonary metastases in both cases. These cases illustrate the importance of close neuroradiological follow-up to detect tumor recurrence in patients with atypical meningiomas WHO grade II even with clinically stable disease and should sensitize clinicians to late extracranial metastases of these tumors, especially to the lung. In an effort to elucidate common clinical features of metastatic meningiomas, especially to the lung, the literature was reviewed from 1995 to 2014, identifying a total of 45 published cases.
机译：我们介绍了两例具有非典型脑膜瘤的世界卫生组织II级病例，这些病例具有多个局部复发和晚期肺转移的病史。在1p和22q上进行的比较细胞遗传学分析证实了两种情况下原发性颅内脑膜瘤的克隆起源和肺转移。这些病例说明了密切的神经放射学随访对即使是临床稳定疾病的非典型脑膜瘤WHO II级患者也要检测肿瘤复发的重要性，并且应该使临床医生对这些肿瘤的晚期颅外转移敏感，尤其是对肺。为了阐明转移性脑膜瘤的常见临床特征，特别是肺部转移性脑膜瘤，从1995年至2014年对文献进行了回顾，共鉴定了45例已发表的病例。

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