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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Globoid cell leukodystrophy (Krabbe’s disease) in a Japanese domestic cat.
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Globoid cell leukodystrophy (Krabbe’s disease) in a Japanese domestic cat.

机译：日本家猫的球状细胞白细胞营养不良（克拉比氏病）。

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摘要

A male Japanese domestic cat developed progressive limb paralysis from 4 months of age. The cat showed visual disorder, trismus and cognitive impairment and died at 9 months of age. At necropsy, significant discoloration of the white matter was observed throughout the brain and spinal cord. Histologically, severe myelin loss and gliosis were observed, especially in the internal capsule and cerebellum.In the lesions, severe infiltration of macrophages with broad cytoplasm filled with PAS-positive and nonmetachromatic granules (globoid cells) was evident. On the basis of these findings, the case was diagnosed as feline globoid cell leukodystrophy (Krabbe’s disease). Immunohistochemical observation indicated the involvement of oxidative stress and small HSP in the disease.
机译：一只雄性日本家猫从4个月大开始发展为四肢瘫痪。这只猫表现出视觉障碍，三头肌和认知障碍，并在9个月大时死亡。尸检时，在整个大脑和脊髓中观察到白质明显变色。组织学上观察到严重的髓磷脂丢失和神经胶质增生，特别是在内囊和小脑中。在病变中，明显可见巨噬细胞浸润有广泛的细胞质，充满了PAS阳性和非异色颗粒（球状细胞）。根据这些发现，该病例被诊断为猫类球状细胞白细胞营养不良（克拉布氏病）。免疫组织化学观察表明该疾病涉及氧化应激和小的HSP。

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