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首页> 外文期刊>Neuron >TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction.
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TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction.

机译：TRPA1有助于感冒，机械和化学伤害，但对于毛细胞转导不是必需的。

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摘要

TRPA1, a member of the transient receptor potential (TRP) family of ion channels, is expressed by dorsal root ganglion neurons and by cells of the inner ear, where it has proposed roles in sensing sound, painful cold, and irritating chemicals. To test the in vivo roles of TRPA1, we generated a mouse in which the essential exons required for proper function of the Trpa1 gene were deleted. Knockout mice display behavioral deficits in response to mustard oil, to cold ( approximately 0 degrees C), and to punctate mechanical stimuli. These mice have a normal startle reflex to loud noise, a normal sense of balance, a normal auditory brainstem response, and normal transduction currents in vestibular hair cells. TRPA1 is apparently not essential for hair-cell transduction but contributes to the transduction of mechanical, cold, and chemical stimuli in nociceptor sensory neurons.
机译：TRPA1是离子通道瞬态受体电位（TRP）家族的成员，由背根神经节神经元和内耳细胞表达，它们在感觉声音，疼痛感冒和刺激性化学物质中起着重要作用。为了测试TRPA1在体内的作用，我们产生了一只小鼠，其中删除了Trpa1基因正常功能所需的必需外显子。敲除小鼠表现出对芥末油，寒冷（约0摄氏度）和点状机械刺激的行为缺陷。这些小鼠对吵闹的声音具有正常的惊吓反射，正常的平衡感，正常的听觉脑干反应以及前庭毛细胞中的正常传导电流。 TRPA1显然不是毛细胞转导所必需的，但有助于伤害感受器感觉神经元的机械，冷和化学刺激的转导。

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