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首页> 外文期刊>Neuron >Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia.
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Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia.

机译：截瘫大鼠的功能恢复和嗅鞘神经胶质细胞的脊髓运动轴突再生。

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Axonal regeneration in the lesioned mammalian central nervous system is abortive, and this causes permanent disabilities in individuals with spinal cord injuries. In adult rats, olfactory ensheathing glia (OEG) transplants successfully led to functional and structural recovery after complete spinal cord transection. From 3 to 7 months post surgery, all OEG-transplanted animals recovered locomotor functions and sensorimotor reflexes. They presented voluntary hindlimb movements, they supported their body weight, and their hindlimbs responded to light skin contact and proprioceptive stimuli. In addition, relevant motor axons (corticospinal, raphespinal, and coeruleospinal) regenerated for long distances within caudal cord stumps. Therefore, OEG transplantation provides a useful repair strategy in adult mammals with traumatic spinal cord injuries. Our results with these cells could lead to new therapies for the treatment of spinal cord lesions in humans.
机译：病变的哺乳动物中枢神经系统中的轴突再生是流产的，这导致脊髓损伤的个体永久性残疾。在成年大鼠中，嗅鞘神经胶质细胞（OEG）移植成功地导致了脊髓完全横断后的功能和结构恢复。手术后3至7个月，所有OEG移植的动物恢复了运动功能和感觉运动反射。他们表现出自愿的后肢运动，支持体重，后肢对轻度皮肤接触和本体感受刺激做出反应。此外，相关的运动轴突（皮质脊髓，短尾轴和蓝皮脊髓）在尾根残端内长距离再生。因此，OEG移植为脊髓损伤性成年哺乳动物提供了有用的修复策略。我们对这些细胞的研究结果可能会导致治疗人类脊髓损伤的新疗法。

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