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首页> 外文期刊>Neuron >LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development.
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LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development.

机译：LIG家族受体酪氨酸激酶相关蛋白在神经发育过程中调节生长因子信号。

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摘要

Genome-wide screens were performed to identify transmembrane proteins that mediate axonal growth, guidance and target field innervation of somatosensory neurons. One gene, Linx (alias Islr2), encoding a leucine-rich repeat and immunoglobulin (LIG) family protein, is expressed in a subset of developing sensory and motor neurons. Domain and genomic structures of Linx and other LIG family members suggest that they are evolutionarily related to Trk receptor tyrosine kinases (RTKs). Several LIGs, including Linx, are expressed in subsets of somatosensory and motor neurons, and select members interact with TrkA and Ret RTKs. Moreover, axonal projection defects in mice harboring a null mutation in Linx resemble those in mice lacking Ngf, TrkA, and Ret. In addition, Linx modulates NGF-TrkA- and GDNF-GFRalpha1/Ret-mediated axonal extension in cultured sensory and motor neurons, respectively. These findings show that LIGs physically interact with RTKs and modulate their activities to control axonal extension, guidance and branching.
机译：进行全基因组筛选，以鉴定介导体感神经元轴突生长，指导和靶场神经支配的跨膜蛋白。一种基因，Linx（别名为Islr2），编码富含亮氨酸的重复序列和免疫球蛋白（LIG）家族蛋白，在发育中的感觉和运动神经元子集中表达。 Linx和其他LIG家族成员的结构域和基因组结构表明它们与Trk受体酪氨酸激酶（RTKs）进化相关。几种Ling，包括Linx，在体感和运动神经元的子集中表达，并且选择的成员与TrkA和Ret RTK相互作用。此外，在Linx中具有无效突变的小鼠中，轴突投射缺陷与缺乏Ngf，TrkA和Ret的小鼠中的相似。此外，Linx分别调节培养的感觉神经元和运动神经元中的NGF-TrkA-和GDNF-GFRalpha1 / Ret介导的轴突扩展。这些发现表明，LIG与RTK发生物理相互作用，并调节其活动以控制轴突的延伸，引导和分支。

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