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首页> 外文期刊>Neuron >Structural MRI of pediatric brain development: what have we learned and where are we going?
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Structural MRI of pediatric brain development: what have we learned and where are we going?

机译：小儿大脑发育的结构MRI：我们学到了什么，我们要去哪里？

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Magnetic resonance imaging (MRI) allows unprecedented access to the anatomy and physiology of the developing brain without the use of ionizing radiation. Over the past two decades, thousands of brain MRI scans from healthy youth and those with neuropsychiatric illness have been acquired and analyzed with respect to diagnosis, sex, genetics, and/or psychological variables such as IQ. Initial reports comparing size differences of various brain components averaged across large age spans have given rise to longitudinal studies examining trajectories of development over time and evaluations of neural circuitry as opposed to structures in isolation. Although MRI is still not of routine diagnostic utility for evaluation of pediatric neuropsychiatric disorders, patterns of typical versus atypical development have emerged that may elucidate pathologic mechanisms and suggest targets for intervention. In this review we summarize general contributions of structural MRI to our understanding of neurodevelopment in health and illness.
机译：磁共振成像（MRI）可在不使用电离辐射的情况下，以前所未有的方式进入发育中的大脑的解剖结构和生理状态。在过去的二十年中，已经获得了成千上万的健康青年和患有神经精神疾病的大脑的MRI扫描结果，并进行了诊断，性别，遗传学和/或心理变量（例如IQ）方面的分析。最初的报告比较了跨大年龄段平均各个大脑组件的大小差异，已经引起了纵向研究，这些研究检查了随着时间推移的发展轨迹，并评估了神经回路而不是孤立的结构。尽管MRI仍不能用于评估小儿神经精神疾病的常规诊断作用，但已出现典型发展与非典型发展的模式，可阐明其病理机制并提出干预目标。在这篇综述中，我们总结了结构性磁共振成像对我们对健康和疾病中神经发育的理解的一般贡献。

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