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首页> 外文期刊>Neuron >Intracranial EEG correlates of expectancy and memory formation in the human hippocampus and nucleus accumbens.
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Intracranial EEG correlates of expectancy and memory formation in the human hippocampus and nucleus accumbens.

机译：颅内脑电图与人类海马和伏隔核的预期和记忆形成相关。

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The human brain is adept at anticipating upcoming events, but in a rapidly changing world, it is essential to detect and encode events that violate these expectancies. Unexpected events are more likely to be remembered than predictable events, but the underlying neural mechanisms for these effects remain unclear. We report intracranial EEG recordings from the hippocampus of epilepsy patients, and from the nucleus accumbens of depression patients. We found that unexpected stimuli enhance an early (187 ms) and a late (482 ms) hippocampal potential, and that the late potential is associated with successful memory encoding for these stimuli. Recordings from the nucleus accumbens revealed a late potential (peak at 475 ms), which increases in magnitude during unexpected items, but no subsequent memory effect and no early component. These results are consistent with the hypothesis that activity in a loop involving the hippocampus and the nucleus accumbens promotes encoding of unexpected events.
机译：人脑善于预测即将发生的事件，但是在瞬息万变的世界中，检测和编码违反这些期望的事件至关重要。与可预见的事件相比，意外事件更容易被记住，但是对于这些影响的潜在神经机制仍然不清楚。我们报告了癫痫患者海马和抑郁症患者伏隔核的颅内脑电图记录。我们发现意外的刺激会增强海马的早期（187 ms）和晚期（482 ms）的潜能，而晚期的潜能与这些刺激的成功记忆编码有关。来自伏隔核的记录显示出晚期电位（峰值在475毫秒），在意外事件期间其幅度增加，但没有随后的记忆效应，也没有早期成分。这些结果与假说有关，即涉及海马体和伏隔核的循环中的活动会促进意外事件的编码。

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