首页> 外文期刊>Neuron >In search of a consensus model of the resting state of a voltage-sensing domain.
【24h】

In search of a consensus model of the resting state of a voltage-sensing domain.

机译:在寻找电压感应域静止状态的共识模型。

获取原文
获取原文并翻译 | 示例
           

摘要

Voltage-sensing domains (VSDs) undergo conformational changes in response to the membrane potential and are the critical structural modules responsible for the activation of voltage-gated channels. Structural information about the key conformational states underlying voltage activation is currently incomplete. Through the use of experimentally determined residue-residue interactions as structural constraints, we determine and refine a model of the Kv channel VSD in the resting conformation. The resulting structural model is in broad agreement with results that originate from various labs using different techniques, indicating the emergence of a consensus for the structural basis of voltage sensing.
机译:电压感应域(VSD)响应膜电位而发生构象变化,是负责激活电压门控通道的关键结构模块。有关电压激活基础的关键构象状态的结构信息目前尚不完整。通过使用实验确定的残基-残基相互作用作为结构约束,我们确定并完善了静止构象中Kv通道VSD的模型。最终的结构模型与来自使用不同技术的各个实验室的结果大体一致,表明出现了电压感测结构基础的共识。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号