...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Dual roles of notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells.
【24h】

Dual roles of notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells.

机译：缺口在调节神经上皮细胞的根尖限制的有丝分裂和apapobasal极性的双重作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

How the mitosis of neuroepithelial stem cells is restricted to the apical ventricular area remains unclear. In zebrafish, the mosaic eyes(rw306) (moe/epb41l5(rw306)) mutation disrupts the interaction between the putative adaptor protein Moe and the apicobasal polarity regulator Crumbs (Crb), and impairs the maintenance of neuroepithelial apicobasal polarity. While Crb interacts directly with Notch and inhibits its activity, Moe reverses this inhibition. In the moe(rw306) hindbrain, Notch activity is significantly reduced, and the number of cells that proliferate basally away from the apical area is increased. Surprisingly, activation of Notch in the moe(rw306) mutant rescues not only the basally localized proliferation but also the aberrant neuroepithelial apicobasal polarity. We present evidence that the CrbMoe complex and Notch play key roles in a positive feedback loop to maintain the apicobasal polarity and the apical-high basal-low gradient of Notch activity in neuroepithelial cells, both of which are essential for their apically restricted mitosis.
机译：尚不清楚如何将神经上皮干细胞的有丝分裂限制在心室顶端区域。在斑马鱼中，镶嵌眼睛（rw306）（moe / epb41l5（rw306））突变破坏了假定的衔接子蛋白Moe与apapobasal极性调节剂Crumbs（Crb）之间的相互作用，并损害了神经上皮apobobasal极性的维持。虽然Crb与Notch直接相互作用并抑制其活性，但Moe逆转了这种抑制作用。在moe（rw306）后脑中，Notch活性显着降低，并且远离顶区域的基底增殖细胞数量增加。出人意料的是，moe（rw306）突变体中的Notch的激活不仅可以挽救基础上的局部增殖，而且还可以挽救异常的神经上皮apapobasal极性。我们提供的证据表明，CrbMoe复合物和Notch在正反馈回路中发挥关键作用，以维持神经上皮细胞的顶突极性和Notch活性的顶高-基低-梯度，这两者对于它们的顶基限制的有丝分裂都是必不可少的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号