Molecular analysis of gene expression in the developing pontocerebellar projection system.

Diaz E; Ge Y; Yang YH; Loh KC; Serafini TA; Okazaki Y; Hayashizaki Y; Speed TP; Ngai J; Scheiffele P

首页> 外文期刊>Neuron >Molecular analysis of gene expression in the developing pontocerebellar projection system.

【24h】

Molecular analysis of gene expression in the developing pontocerebellar projection system.

机译：发育中的小脑投射系统中基因表达的分子分析。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

As an approach toward understanding the molecular mechanisms of neuronal differentiation, we utilized DNA microarrays to elucidate global patterns of gene expression during pontocerebellar development. Through this analysis, we identified groups of genes specific to neuronal precursor cells, associated with axon outgrowth, and regulated in response to contact with synaptic target cells. In the cerebellum, we identified a phase of granule cell differentiation that is independent of interactions with other cerebellar cell types. Analysis of pontine gene expression revealed that distinct programs of gene expression, correlated with axon outgrowth and synapse formation, can be decoupled and are likely influenced by different cells in the cerebellar target environment. Our approach provides insight into the genetic programs underlying the differentiation of specific cell types in the pontocerebellar projection system.

机译：作为了解神经元分化的分子机制的一种方法，我们利用DNA微阵列阐明了小脑发育过程中基因表达的整体模式。通过此分析，我们确定了特定于神经元前体细胞的基因组，这些基因组与轴突的生长相关，并在响应与突触靶细胞的接触时受到调节。在小脑，我们确定了颗粒细胞分化的阶段，独立于与其他小脑细胞类型的相互作用。桥脑基因表达的分析显示，与轴突生长和突触形成相关的基因表达的不同程序可以解偶联，并且可能受小脑靶标环境中不同细胞的影响。我们的方法提供了洞察小脑投射系统中特定细胞类型分化的遗传程序的见解。

著录项

来源
《Neuron》 |2002年第3期|共18页
作者
Diaz E; Ge Y; Yang YH; Loh KC; Serafini TA; Okazaki Y; Hayashizaki Y; Speed TP; Ngai J; Scheiffele P;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经生理学;
关键词
Gene Expression; differentiation; Projections and Predictions; Analysis of substances; 基因表达;

机译：基因表达;分化;预测与预测;物质分析;基因表达;

相似文献

外文文献
中文文献
专利

1. Molecular analysis of gene expression in the developing pontocerebellar projection system. [J] . Diaz E, Ge Y, Yang YH, Neuron . 2002,第3期

机译：发育中的小脑投射系统中基因表达的分子分析。
2. Molecular cloning and expression analysis of multiple polyphenol oxidase genes in developing wheat (Triticum aestivum) kernels. [J] . Beecher B, Skinner D. Z. Journal of Cereal Science . 2011,第3期

机译：发育中的小麦（ Triticum aestivum ）仁中多个多酚氧化酶基因的分子克隆和表达分析。
3. Regional expression of MTG genes in the developing mouse central nervous system. [J] . Alishahi A, Koyano Nakagawa N, Nakagawa Y Developmental dynamics: an official publication of the American Association of Anatomists . 2009,第8期

机译：MTG基因在发育中的小鼠中枢神经系统中的区域表达。
4. Implementation of Factor Analysis for Bicluster Acquisition: Sparseness Projection (FABIAS) on Microarray of Alzheimer's Gene Expression Data [C] . Theresia B. P. Wutun, Alhadi Bustamam, Titin Siswantining Symposium on Biomathematics . 2018

机译：双裂读因子分析的实施：稀疏投影（FABIAS）对阿尔茨海默氏症基因表达数据的微阵列
5. The role of neurotrophin-dependent gene expression in the developing somatosensory nervous system. [D] . Wickramasinghe, Sasrutha Rasika. 2009

机译：神经营养蛋白依赖性基因表达在发育的体感神经系统中的作用。
6. A Comparative Molecular Analysis of Developing Mouse Forelimbs and Hindlimbs Using Serial Analysis of Gene Expression (SAGE) [O] . Elliott H. Margulies, Sharon L.R. Kardia, Jeffrey W. Innis 2001

机译：利用基因表达序列分析（SAGE）对发育中的小鼠前肢和后肢进行比较分子分析
7. Molecular Analysis of Gene Expression in the Developing Pontocerebellar Projection System [O] . Dı́az Elva, Ge Yongchao, Yang Yee Hwa, 2002

机译：发育中的小脑投射系统中基因表达的分子分析

Molecular analysis of gene expression in the developing pontocerebellar projection system.

摘要

著录项

相似文献

相关主题

期刊订阅