...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >A nodal signaling pathway regulates the laterality of neuroanatomical asymmetries in the zebrafish forebrain.
【24h】

A nodal signaling pathway regulates the laterality of neuroanatomical asymmetries in the zebrafish forebrain.

机译：节点信号通路调节斑马鱼前脑中神经解剖学不对称性的侧向性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Animals show behavioral asymmetries that are mediated by differences between the left and right sides of the brain. We report that the laterality of asymmetric development of the diencephalic habenular nuclei and the photoreceptive pineal complex is regulated by the Nodal signaling pathway and by midline tissue. Analysis of zebrafish embryos with compromised Nodal signaling reveals an early role for this pathway in the repression of asymmetrically expressed genes in the diencephalon. Later signaling mediated by the EGF-CFC protein One-eyed pinhead and the forkhead transcription factor Schmalspur is required to overcome this repression. When expression of Nodal pathway genes is either absent or symmetrical, neuroanatomical asymmetries are still established but are randomized. This indicates that Nodal signaling is not required for asymmetric development per se but is essential to determine the laterality of the asymmetry.
机译：动物表现出的行为不对称是由大脑左右两侧之间的差异所介导的。我们报告说，Nondal信号通路和中线组织调节二脑ha状核和光感受松果体的不对称发展的偏侧性。斑马鱼胚胎具有受损的节点信号的分析表明该途径在抑制间脑中不对称表达的基因中的早期作用。需要通过EGF-CFC蛋白“单眼针头形”和“叉头形转录因子” Schmalspur介导的后续信号来克服这种抑制作用。当节点信号途径基因的表达不存在或不对称时，神经解剖学上的不对称仍然存在，但被随机化。这表明节点信号本身对于不对称显影不是必需的，但对于确定不对称的横向性是必不可少的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号