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首页> 外文期刊>Neuron >A highly Ca2+-sensitive pool of vesicles contributes to linearity at the rod photoreceptor ribbon synapse.
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A highly Ca2+-sensitive pool of vesicles contributes to linearity at the rod photoreceptor ribbon synapse.

机译：Ca2 +高度敏感的囊泡池有助于杆感光带突触的线性。

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摘要

Studies of the properties of synaptic transmission have been carried out at only a few synapses. We analyzed exocytosis from rod photoreceptors with a combination of physiological and ultrastructural techniques. As at other ribbon synapses, we found that rods exhibited rapid kinetics of release, and the number of vesicles in the releasable pool is comparable to the number of vesicles tethered at ribbon-style active zones. However, unlike other previously studied neurons, we identified a highly Ca(2+)-sensitive pool of releasable vesicles with a relatively shallow relationship between the rate of exocytosis and [Ca(2+)](i) that is nearly linear over a presumed physiological range of intraterminal [Ca(2+)]. The low-order [Ca(2+)] dependence of release promotes a linear relationship between Ca(2+) entry and exocytosis that permits rods to relay information about small changes in illumination with high fidelity at the first synapse in vision.
机译：仅在少数突触中进行了突触传递特性的研究。我们结合生理学和超微结构技术分析了杆状光感受器的胞吐作用。像其他的带状突触一样，我们发现杆表现出快速的释放动力学，可释放池中的囊泡数量可与束带式活性区拴系的囊泡数量相比。但是，与其他先前研究的神经元不同，我们确定了高度Ca（2+）敏感的可释放囊泡，其胞吐速率与[Ca（2 +）]（i）之间的线性关系相对较浅。终端[Ca（2+）]的生理范围。释放的低阶[Ca（2+）]依赖性促进Ca（2+）进入与胞吐作用之间的线性关系，从而允许视标在视觉的第一个突触处以高保真度传递有关照明小变化的信息。

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