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首页> 外文期刊>Neuron >GABAergic Projection Neurons Route Selective Olfactory Inputs to Specific Higher-Order Neurons
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GABAergic Projection Neurons Route Selective Olfactory Inputs to Specific Higher-Order Neurons

机译：GABA能投影神经元将选择性嗅觉输入传递给特定的高阶神经元

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摘要

We characterize an inhibitory circuit motif in the Drosophila olfactory system, parallel inhibition, which differs from feedforward or feedback inhibition. Excitatory and GABAergic inhibitory projection neurons (ePNs and iPNs) each receive input from antennal lobe glomeruli and send parallel output to the lateral horn, a higher center implicated in regulating innate olfactory behavior. Ca2+ imaging of specific lateral horn neurons as an olfactory readout revealed that iPNs selectively suppressed food-related odor responses, but spared signal transmission from pheromone channels. Coapplying food odorant did not affect pheromone signal transmission, suggesting that the differential effects likely result from connection specificity of iPNs, rather than a generalized inhibitory tone. Ca2+ responses in the ePN axon terminals show no detectable suppression by iPNs, arguing against presynaptic inhibition as a primary mechanism. The parallel inhibition motif may provide specificity in inhibition to funnel specific olfactory information, such as food and pheromone, into distinct downstream circuits.
机译：我们表征果蝇嗅觉系统中的抑制电路主题，平行抑制，不同于前馈或反馈抑制。兴奋性和GABA抑制性投射神经元（ePN和iPN）各自从触角小叶肾小球接收输入，并将并行输出发送到侧角，这是涉及调节先天嗅觉行为的较高中心。作为嗅觉读出的特定侧角神经元的Ca2 +成像显示，iPNs选择性抑制了食物相关的气味反应，但保留了来自信息素通道的信号传输。并用食品增香剂不会影响信息素的信号传递，这表明差异作用可能是由于iPNs的连接特异性而不是普遍的抑制音引起的。 ePN轴突末端中的Ca2 +响应未显示iPNs可检测到的抑制作用，认为突触前抑制是主要机制。平行抑制基序可以提供抑制特异性，以将特定的嗅觉信息（例如食物和信息素）漏入不同的下游回路中。

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