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首页> 外文期刊>Neuron >BDNF mediates the effects of testosterone on the survival of new neurons in an adult brain.
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BDNF mediates the effects of testosterone on the survival of new neurons in an adult brain.

机译：BDNF介导睾丸激素对成年大脑中新神经元存活的影响。

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摘要

New neurons are incorporated into the high vocal center (HVC), a nucleus of the adult canary (Serinus canaria) brain that plays a critical role in the acquisition and production of learned song. Recruitment of new neurons in the HVC is seasonally regulated and depends upon testosterone levels. We show here that brain-derived neurotrophic factor (BDNF) is present in the HVC of adult males but is not detectable in that of females, though the HVC of both sexes has BDNF receptors (TrkB). Testosterone treatment increases the levels of BDNF protein in the female HVC, and BDNF infused into the HVC of adult females triples the number of new neurons. Infusion of a neutralizing antibody to BDNF blocks the testosterone-induced increase in new neurons. Our results demonstrate that BDNF is involved in the regulation of neuronal replacement in the adult canary brain and suggest that the effects of testosterone are mediated through BDNF.
机译：新的神经元被整合到成年金丝雀（Serinus canaria）脑核的高声中枢（HVC）中，在获取和产生所学歌曲中起着关键作用。 HVC中新神经元的募集受到季节调节，并取决于睾丸激素水平。我们在这里显示，成年男性的HVC中存在脑源性神经营养因子（BDNF），但在女性的HVC中却无法检测到，尽管两性的HVC具有BDNF受体（TrkB）。睾丸激素治疗会增加雌性HVC中BDNF蛋白的水平，而注入成年雌性HVC中的BDNF会使新神经元的数量增加三倍。输注针对BDNF的中和抗体可阻止睾丸激素诱导的新神经元增加。我们的结果表明，BDNF参与了成年金丝雀大脑神经元替代的调控，并表明睾丸激素的作用是通过BDNF介导的。

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