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首页> 外文期刊>Neuron >Optical imaging of odorant representations in the mammalian olfactory bulb.
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Optical imaging of odorant representations in the mammalian olfactory bulb.

机译：哺乳动物嗅球中的气味表示的光学成像。

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摘要

We adapted the technique of intrinsic signal imaging to visualize how odorant concentration and structure are represented spatially in the rat olfactory bulb. Most odorants activated one or more glomeruli in the imaged region of the bulb; these optically imaged responses reflected the excitation of underlying neurons. Odorant-evoked patterns were similar across animals and symmetrical in the two bulbs of the same animal. The variable sensitivity of individual glomeruli produced distinct maps for different odorant concentrations. Using a series of homologous aldehydes, we found that glomeruli were tuned to detect particular molecular features and that maps of similar molecules were highly correlated. These characteristics suggest that odorants and their concentrations can be encoded by distinct spatial patterns of glomerular activation.
机译：我们采用了内在信号成像技术，以可视化在大鼠嗅球中如何在空间上表示气味的浓度和结构。大多数气味物质会在灯泡的成像区域中激活一个或多个肾小球。这些光学成像的反应反映了潜在神经元的兴奋。异味诱发的模式在动物之间相似，并且在同一只动物的两个鳞茎中对称。单个肾小球的可变敏感性产生了针对不同气味剂浓度的不同图。使用一系列同源醛，我们发现调节肾小球以检测特定的分子特征，并且相似分子的图谱高度相关。这些特征表明，气味剂及其浓度可以由肾小球活化的不同空间模式编码。

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