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首页> 外文期刊>Neuron >Locomotor Rhythm Generation Linked to the Output of Spinal Shox2 Excitatory Interneurons
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Locomotor Rhythm Generation Linked to the Output of Spinal Shox2 Excitatory Interneurons

机译：运动节律的产生与脊髓Shox2兴奋性interneurons的输出联系在一起。

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摘要

Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilaterally projecting excitatory interneuron population, marked by the expression of Shox2 that overlaps partially with V2a interneurons. Optogenetic silencing or blocking synaptic output of Shox2 interneurons (INs) in transgenic mice perturbed rhythm without an effect on pattern generation, whereas ablation of the Shox2 IN subset coinciding with the V2a population was without effect. Most Shox2 INs are rhythmically active during locomotion and analysis of synaptic connectivity showed that Shox2 INs contact other Shox2 INs, commissural neurons, and motor neurons,with preference for flexor motor neurons. Our findings focus attention on a subset of Shox2 INs that appearto participate in the rhythm-generating kernel for spinal locomotion.
机译：运动是由产生节律并协调左右，左右伸肌图形的脊柱网络控制的。脊髓神经元的定义种群已经与构图电路联系在一起。然而，构成节律产生核的神经元仍然难以捉摸。在这里，我们确定了同侧投射的兴奋性中间神经元群体，其特征在于与V2a中间神经元部分重叠的Shox2表达。转基因小鼠中的Shox2 interneurons（INs）的光遗传沉默或阻止突触输出扰动节奏，不影响模式生成，而消融与V2a群体一致的Shox2 IN子集无效。大多数Shox2 IN在运动过程中具有节律性，对突触连接性的分析表明，Shox2 IN与其他Shox2 IN，连合神经元和运动神经元接触，偏向于屈肌运动神经元。我们的发现集中在Shox2 IN的一个子集上，该子集似乎参与了产生节律的脊髓运动。

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