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首页> 外文期刊>Neuron >Plasticity of Recurrent L2/3 Inhibition and Gamma Oscillations by Whisker Experience
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Plasticity of Recurrent L2/3 Inhibition and Gamma Oscillations by Whisker Experience

机译：晶须经验对重复性L2 / 3抑制和伽玛振荡的可塑性

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摘要

Local recurrent networks in neocortex are critical nodes for sensory processing, but their regulation by experience is much less understood than for long-distance (translaminar or cross-columnar) projections. We studied local L2/3 recurrent networks in rat somatosensory cortex during deprivation-induced whisker map plasticity, by expressing channelrhodopsin-2 (ChR2) in L2/3 pyramidal cells and measuring light-evoked synaptic currents in exvivo S1 slices. In columns with intact whiskers, brief light impulses evoked recurrent excitation and supralinear inhibition. Deprived columns showed modestly reduced excitation and profoundly reduced inhibition, providing a circuit locus for disinhibition of whisker-evoked responses observed in L2/3 invivo. Slower light ramps elicited sustained gamma frequency oscillations, which were nearly abolished in deprived columns. Reduction in gamma power was also observed in spontaneous LFP oscillations in L2/3 of deprived columns invivo. Thus, L2/3 recurrent networks are a powerful site for homeostatic modulation of excitation-inhibition balance and regulation of gamma oscillations.
机译：新大脑皮层中的局部递归网络是感觉处理的关键节点，但与远距离（跨层或跨柱状）投影相比，它们对经验的调节要少得多。我们在剥夺诱导的晶须图可塑性期间，通过在L2 / 3锥体细胞中表达Channelrhodopsin-2（ChR2）并测量离体S1切片中的光诱发突触电流，研究了大鼠体感皮层局部L2 / 3递归网络。在具有完整晶须的色谱柱中，短暂的光脉冲会引起反复激发和超线性抑制。剥夺的色谱柱显示出适度降低的激发和显着降低的抑制作用，从而为抑制L2 / 3体内观察到的晶须诱发的反应提供了回路场所。较慢的光坡度会引起持续的伽马频率振荡，这在被剥夺的色谱柱中几乎被消除。在剥夺柱体内的L2 / 3的自发LFP振荡中也观察到了伽马功率的降低。因此，L2 / 3递归网络是激发抑制平衡的稳态调节和伽马振荡调节的有力场所。

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