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首页> 外文期刊>Neuron >Fezf2 expression identifies a multipotent progenitor for neocortical projection neurons, astrocytes, and oligodendrocytes
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Fezf2 expression identifies a multipotent progenitor for neocortical projection neurons, astrocytes, and oligodendrocytes

机译：Fezf2表达确定了新皮质投射神经元，星形胶质细胞和少突胶质细胞的多能祖细胞

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摘要

Progenitor cells in the cerebral cortex sequentially generate distinct classes of projection neurons. Recent work suggests the cortex may contain intrinsically fate-restricted progenitors marked by expression of Cux2. However, the heterogeneity ofthe neocortical ventricular zone as well as the contribution of lineage-restricted progenitors to the overall cortical neurogenic program remains unclear. Here, we utilize invivo genetic fate mapping to demonstrate that Fezf2-expressing radial glial cells (RGCs) exist throughout cortical development and sequentially generate all major projection neuron subtypes and glia. Moreover, we show that the vast majority of CUX2+ cells in the VZ and SVZ are migrating interneurons derived from the subcortical telencephalon. Examination of the embryonic cortical progenitor population demonstrates that Cux2+ RGCs generate both deep- and upper-layer projection neurons. These results identify Fezf2+ radial glial cells as a multipotent neocortical progenitor and suggest that the existence, and molecular identity, of laminar-fate-restricted RGCs awaits further investigation.
机译：大脑皮层中的祖细胞顺序生成不同类别的投射神经元。最近的工作表明，皮质可能包含固有的受命运限制的祖细胞，这些祖细胞以Cux2的表达为标志。但是，尚不清楚新皮质心室区的异质性以及谱系受限祖细胞对整个皮质神经发生程序的贡献。在这里，我们利用体内遗传命运图谱来证明表达Fezf2的放射状神经胶质细胞（RGC）存在于整个皮质发育过程中，并依次产生所有主要的投射神经元亚型和神经胶质。此外，我们显示，VZ和SVZ中的绝大多数CUX2 +细胞正在迁移源自皮层下端脑的中间神经元。胚胎皮质祖细胞的检查表明，Cux2 + RGCs产生深层和上层投射神经元。这些结果将Fezf2 +放射状胶质细胞鉴定为多能新皮质祖细胞，并表明层流命运限制的RGC的存在和分子身份正在等待进一步的研究。

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