Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72

Jiang Jie; Cleveland Don W.

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Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72

机译：双向转录抑制作为C9orf72重复扩增引起的ALS / FTD治疗

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Hexanucleotide repeat expansion in the bi-directionally transcribed C9orf72 gene is the most frequent cause of familial ALS and frontotemporal dementia (FTD). Kramer et al. (2016) report in Science that targeted reduction in the transcription elongation factor SUPT4H1/SUPT5H reduces both sense and antisense repeatcontaining RNAs and their associated neurodegeneration.

机译：双向转录的C9orf72基因中的六核苷酸重复扩增是家族性ALS和额颞痴呆（FTD）的最常见原因。 Kramer等。（2016）在《科学》杂志上的报道指出，有针对性地减少转录延伸因子SUPT4H1 / SUPT5H可以减少包含有义和反义重复序列的RNA及其相关的神经变性。

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《Neuron》 |2016年第6期|共4页
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Jiang Jie; Cleveland Don W.;
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正文语种 eng
中图分类神经病学;
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1. Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72 [J] . Jiang Jie, Cleveland Don W. Neuron . 2016,第6期

机译：双向转录抑制作为C9orf72重复扩增引起的ALS / FTD治疗
2. Oligonucleotide-Based Therapy for FTD/ALS Caused by the C9orf72 Repeat Expansion: A Perspective [J] . Fernandes Stephanie A., Douglas Andrew G. L., Varela Miguel A., Journal of Nucleic Acids . 2013,第4期

机译：基于寡核苷酸的C9orf72重复扩增引起的FTD / ALS治疗
3. Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72 [J] . Nature neuroscience . 2020,第5期

机译：减少的C9ORF72功能加剧了在C9ORF72中的ALS / FTD导致重复扩展的毒性的增益
4. Passive repression of HIV-1 long terminal repeat controlled viral transcription by site-directed combinatorial design of artificial DNA-binding protein screened from combinatorial chemical libraries [C] . Stefan R.K.Hoffmann the International Peptide Symposium . 2001

机译：通过组合化学文库筛选的人工DNA结合蛋白的现场定向组合设计的HIV-1长末端重复受控病毒转录的被动抑制
5. Transcriptional Inhibition of (GGGGCC) c9orf72 Hexanucleotide Repeat Expansion in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis [D] . Kim, Yujin E. 2019

机译：在额颞痴呆和肌萎缩性侧索硬化中（GGGGCC）c9orf72六核苷酸重复扩展的转录抑制。
6. Oligonucleotide-Based Therapy for FTD/ALS Caused by the C9orf72 Repeat Expansion: A Perspective [O] . Stephanie A. Fernandes, Andrew G. L. Douglas, Miguel A. Varela, 2013

机译：C9orf72重复扩增引起的基于寡核苷酸的FTD / ALS治疗。
7. Oligonucleotide-based therapy for FTD/ALS caused by the C9orf72 repeat expansion: a perspective [O] . Fernandes Stephanie A., Douglas Andrew G.L., Varela Miguel A., 2013

机译：基于寡核苷酸的治疗由C9orf72重复扩增引起的FTD / aLs：一个观点

Bidirectional Transcriptional Inhibition as Therapy for ALS/FTD Caused by Repeat Expansion in C9orf72

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