The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system (see comments)

Huang ML; Hsu CH; Chien CT

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The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system (see comments)

机译：前神经基因amos促进果蝇外周神经系统中的多个树突状神经元形成（见评论）

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In the Drosophila peripheral nervous system, proneural genes direct the formation of different types of sensory organs. Here, we show that amos is a novel proneural gene that promotes multiple dendritic (MD) neuron formation. amos encodes a basic-helix-loop-helix (bHLH) protein of the Atonal family. During embryonic development, amos is expressed in patches of ectodermal cells, and the expression is quickly restricted to sensory organ precursors. Loss of amos function eliminates MD neurons that remain in ASC;atonal mutants. Misexpression of amos generates ectopic MD and other types of neurons. Amos interacts with the ubiquitously expressed Daughter-less protein in vivo and in vitro. Our final misexpression experiments suggest that a domain located outside the DNA-binding domain of Amos determines the MD neuronal specificity.

机译：在果蝇外周神经系统中，前体神经基因指导不同类型的感觉器官的形成。在这里，我们显示amos是一种新型的proneural基因，可促进多个树突状（MD）神经元的形成。 amos编码Atonal家族的基本螺旋-环-螺旋（bHLH）蛋白。在胚胎发育过程中，amos在外胚层细胞的膜片中表达，并且该表达很快局限于感觉器官的前体。 Amos功能的丧失消除了残留在ASC;突变体中的MD神经元。 Amos的错误表达会产生异位MD和其他类型的神经元。 Amos在体内和体外与无处不在的无子蛋白表达相互作用。我们最终的错误表达实验表明，位于Amos DNA结合结构域之外的结构域决定了MD神经元的特异性。

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《Neuron》 |2000年第1期|共11页
作者
Huang ML; Hsu CH; Chien CT;
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正文语种 eng
中图分类神经生理学;
关键词
Dendrites; Drosophila; Nerve Growth Factors; Neurons; Afferent; Stem Cells; 树突; 果蝇属; 神经生长因子; 神经元; 传入; 干细胞;

机译：Dendrites;Drosophila;Nerve Growth Factors;Neurons;Afferent;Stem Cells;树突;果蝇属;神经生长因子;神经元;传入;干细胞;

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1. The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system (see comments) [J] . Huang ML, Hsu CH, Chien CT Neuron . 2000,第1期

机译：前神经基因amos促进果蝇外周神经系统中的多个树突状神经元形成（见评论）
2. amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge (see comments) [J] . Goulding SE, zur Lage-P, Jarman AP Neuron . 2000,第1期

机译：amos，果蝇嗅觉器官的前神经基因，受锭剂调节（见评论）
3. Tufted Is a Gain-of-Function Allele That Promotes Ectopic Expression of the Proneural Gene amos in Drosophila [J] . Eugenia Villa-Cuesta, Joaquín de Navascués, José Félix de Celis, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2003,第4期

机译：簇绒是促进果蝇中proneural基因amos异位表达的功能获得等位基因
4. Investigation of the relationship of radio-induced apoptosis of Drosophila larvae nervous system and the ageing of imago nervous system [C] . A.A. Moskalev Protection of the Environment from the Effects of Ionizing Radiation . 2005

机译：果蝇幼虫神经系统放射诱导凋亡与成年神经系统衰老关系的研究
5. Genomic exploration of the peripheral nervous system: Identification of candidate genes for neuroblastoma, hearing loss, and other aspects of neuron biology and tumorigenesis [D] . Hackett, Christopher S. 2010

机译：周围神经系统的基因组探索：鉴定神经母细胞瘤，听力损失以及神经元生物学和肿瘤发生的其他方面的候选基因
6. Tufted is a gain-of-function allele that promotes ectopic expression of the proneural gene amos in Drosophila. [O] . Eugenia Villa-Cuesta, Joaquín de Navascués, Mar Ruiz-Gómez, 2003

机译：簇绒是功能增强的等位基因可促进果蝇中前体基因amos的异位表达。
7. The Proneural Gene amos Promotes Multiple Dendritic Neuron Formation in the Drosophila Peripheral Nervous System [O] . Huang Min-Lang, Hsu Chia-Hsin, Chien Cheng-Ting 2000

机译：前体基因amos促进果蝇周围神经系统中的多个树突状神经元形成。

The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system (see comments)

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