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首页> 外文期刊>Neuron >Cell-Type-Specific Activity in Prefrontal Cortex during Goal-Directed Behavior
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Cell-Type-Specific Activity in Prefrontal Cortex during Goal-Directed Behavior

机译：目标定向行为期间前额叶皮层中特定于细胞类型的活动

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摘要

The prefrontal cortex (PFC) plays a key role in controlling goal-directed behavior. Although a variety of task-related signals have been observed in the PFC, whether they are differentially encoded by various cell types remains unclear. Here we performed cellular-resolution microendoscopic Ca2+ imaging from genetically defined cell types in the dorsomedial PFC of mice performing a PFC-dependent sensory discrimination task. We found that inhibitory interneurons of the same subtype were similar to each other, but different subtypes preferentially signaled different task-related events: somatostatin-positive neurons primarily signaled motor action (licking), vasoactive intestinal peptide-positive neurons responded strongly to action outcomes, whereas parvalbumin-positive neurons were less selective, responding to sensory cues, motor action, and trial outcomes. Compared to each interneuron subtype, pyramidal neurons showed much greater functional heterogeneity, and their responses varied across cortical layers. Such cell-type and laminar differences in neuronal functional properties may be crucial for local computation within the PFC microcircuit.
机译：前额叶皮层（PFC）在控制目标导向的行为中起关键作用。尽管在PFC中已观察到各种与任务相关的信号，但尚不清楚它们是否由各种单元类型进行差分编码。在这里，我们从小鼠的背侧PFC中遗传定义的细胞类型中进行了细胞分辨率的微内镜Ca2 +成像，这些小鼠执行PFC依赖的感觉辨别任务。我们发现相同亚型的抑制性神经元彼此相似，但不同亚型优先发出不同任务相关事件的信号：生长抑素阳性神经元主要发出运动信号（舔），血管活性肠肽阳性神经元对动作结果反应强烈，而小白蛋白阳性神经元的选择性较差，对感觉线索，运动功能和试验结果有反应。与每个中间神经元亚型相比，锥体神经元显示出更大的功能异质性，并且它们的反应在整个皮层中各不相同。这种神经元功能特性的细胞类型和层流差异对于PFC微电路内的局部计算可能至关重要。

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