Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies

Gai Yunchao; Liu Ze; Cervantes-Sandoval Isaac; Davis Ronald L.

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Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies

机译：果蝇SLC22A转运蛋白是一个记忆抑制基因，影响胆碱能神经传递到蘑菇体。

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The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Carrier DmSLC22A, a member of the organic cation transporter family, enhances olfactory memory expression, while overexpression inhibits it. The protein localizes to the dendrites of the MBn, surrounding the presynaptic terminals of cholinergic afferent fibers from projection neurons (Pn). Cell-based expression assays show that this plasma membrane protein transports cholinergic compounds with the highest affinity among several in vitro substrates. Feeding flies choline or inhibiting acetylcholinesterase in Pn enhances memory, an effect blocked by overexpression of the transporter in the MBn. The data argue that DmSLC22A is a memory suppressor protein that limits memory formation by helping to terminate cholinergic neurotransmission at the Pn: MBn synapse.

机译：限制记忆形成的机制特别受关注，因为它们提供了对大脑记忆管理系统的了解，并提供了纠正认知障碍的潜在途径。果蝇蘑菇体神经元（MBn）中新发现的记忆抑制基因Solute Carrier DmSLC22A是有机阳离子转运蛋白家族的一员，其RNAi抑制作用增强了嗅觉记忆表达，而过表达抑制了嗅觉记忆表达。该蛋白定位于MBn的树突，围绕着来自投射神经元（Pn）的胆碱能传入纤维的突触前末端。基于细胞的表达测定表明，这种质膜蛋白在几种体外底物中具有最高的亲和力来转运胆碱能化合物。喂食Pn中的胆碱或抑制乙酰胆碱酯酶会增强记忆力，MBn中转运蛋白的过表达会阻止这种效应。数据表明DmSLC22A是一种记忆抑制蛋白，可通过帮助终止Pn：MBn突触处的胆碱能神经传递来限制记忆形成。

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《Neuron》 |2016年第3期|共15页
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Gai Yunchao; Liu Ze; Cervantes-Sandoval Isaac; Davis Ronald L.;
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1. Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies [J] . Gai Yunchao, Liu Ze, Cervantes-Sandoval Isaac, Neuron . 2016,第3期

机译：果蝇SLC22A转运蛋白是一个记忆抑制基因，影响胆碱能神经传递到蘑菇体。
2. Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling in Drosophila melanogaster [J] . Yves F. Widmer, Adem Bilican, Rémy Bruggmann, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2018,第4期

机译：果蝇蘑菇体内特定基因表达谱揭示的长期记忆的调节剂。
3. Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling in Drosophila melanogaster [J] . Widmer Yves F., Bilican Adem, Bruggmann Remy, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2018,第4期

机译：Mushroom特异性基因表达探讨在果蝇Melanogaster中揭示的长期记忆监管机构
4. The Influence of Polysaccharides from Lentinula edodes Mushroom on The Food Intake and Body Weight of Drosophila melanogaster [C] . MATJUSKOVA N., E.AZENA, K.SERSTNOVA, The 7th international medicinal mushroom conference . 2013

机译：香菇菌丝多糖对黑腹果蝇食物摄入及体重的影响
5. Genes involved in mushroom body development and behavior in Drosophila. [D] . Serway, Christine Nicole. 2010

机译：果蝇中与蘑菇体发育和行为有关的基因。
6. Drosophila SLC22A transporter is a memory suppressor gene that influences cholinergic neurotransmission to the mushroom bodies [O] . Yunchao Gai, Ze Liu, Isaac Cervantes-Sandoval, -1

机译：果蝇SLC22A转运蛋白是一个记忆抑制基因影响胆碱能神经向蘑菇体的传递。
7. Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies [O] . Yunchao Gai, Ze Liu, Isaac Cervantes-Sandoval, 2016

机译：果蝇SLC22A转运仪是一种记忆抑制基因，影响胆碱能神经递质对蘑菇体

Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies

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