hnRNPA2/B1 Function in Neurodegeneration: It's a Gain, Not a Loss

Hutten Saskia; Dormann Dorothee

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hnRNPA2/B1 Function in Neurodegeneration: It's a Gain, Not a Loss

机译：hnRNPA2 / B1在神经退行性疾病中的作用：是收获，而不是损失

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hnRNPA2B1 is linked to several neurodegenerative disorders, yet its roles in the CNS have been largely unknown. In this issue of Neuron, Martinez et al. (2016) present the first transcriptome-wide analysis of hnRNPA2B1 targets and function in the nervous system.

机译：hnRNPA2B1与数种神经退行性疾病相关，但在CNS中的作用尚不清楚。在本期《神经元》中，马丁内斯等人。（2016年）提出了hnRNPA2B1靶标和神经系统功能的第一个转录组范围的分析。

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《Neuron》 |2016年第4期|共3页
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Hutten Saskia; Dormann Dorothee;
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正文语种 eng
中图分类神经病学;
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1. hnRNPA2/B1 Function in Neurodegeneration: It's a Gain, Not a Loss [J] . Hutten Saskia, Dormann Dorothee Neuron . 2016,第4期

机译：hnRNPA2 / B1在神经退行性疾病中的作用：是收获，而不是损失
2. Dissecting TDP-43 gain- and loss-of-function in neurodegeneration [J] . Sivakumar P., Humphrey J., Lo K., Neuromuscular disorders: NMD . 2018,第Suppla1期

机译：解剖TDP-43在神经变性中的增益和功能丧失
3. Dissecting TDP-43 gain- and loss-of-function in neurodegeneration [J] . Sivakumar P., Humphrey J., Lo K., Neuromuscular disorders: NMD . 2018,第Suppla1期

机译：解剖TDP-43在神经变性中的增益和功能丧失
4. Classification of Mutations by Functional Impact Type: Gain of Function, Loss of Function, and Switch of Function [C] . Mingming Liu, Layne T. Watson, Liqing Zhang International symposium on bioinformatics research and applications . 2014

机译：按功能影响类型对突变进行分类：功能获得，功能丧失和功能转换
5. Clinical Validity of a Gain-of-Function/Loss-of-Function Predictive Computational Tool [D] . Bogyo, Kelsie 2019

机译：功能获得/功能丧失预测计算工具的临床有效性
6. Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes [O] . Danielle C. Diaper, Yoshitsugu Adachi, Ben Sutcliffe, -1

机译：果蝇TDP-43的丧失和获得损害突触功效和运动控制导致功能丧失表型导致与年龄相关的神经变性
7. Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes [O] . Diaper Danielle C, Adachi Yoshitsugu, Sutcliffe Ben, 2013

机译：果蝇TDp-43的损失和增加损害突触功效和运动控制，导致功能丧失表型导致年龄相关的神经变性

hnRNPA2/B1 Function in Neurodegeneration: It's a Gain, Not a Loss

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