Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin.

Berke JD; Sgambato V; Zhu PP; Lavoie B; Vincent M; Krause M; Hyman SE

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Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin.

机译：多巴胺和谷氨酸诱导不同的纹状体剪接形式的Ania-6（一种与RNA聚合酶II相关的细胞周期蛋白）。

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Control of neuronal gene expression by drugs or neurotransmitters is a critical step in long-term neural plasticity. Here, we show that a gene induced in the striatum by cocaine or direct dopamine stimulation, ania-6, is a member of a novel family of cyclins with homology to cyclins K/T/H/C. Further, different types of neurotransmitter stimulation cause selective induction of distinct ania-6 isoforms, through alternative splicing. The longer Ania-6 protein colocalizes with nuclear speckles and is associated with key elements of the RNA elongation/processing complex, including the hyperphosphorylated form of RNA polymerase II, the splicing factor SC-35, and the p110 PITSLRE cyclin-dependent kinase. Distinct types of neuronal stimulation may therefore differentially modulate nuclear RNA processing, through altered transcription and splicing of ania-6.

机译：通过药物或神经递质控制神经元基因表达是长期神经可塑性的关键步骤。在这里，我们显示通过可卡因或直接多巴胺刺激在纹状体中诱导的基因ania-6，是与周期蛋白K / T / H / C具有同源性的新型周期蛋白家族的成员。此外，不同类型的神经递质刺激通过交替剪接引起不同的ania-6亚型的选择性诱导。较长的Ania-6蛋白与核斑点共定位，并与RNA延伸/加工复合体的关键元件相关，包括RNA聚合酶II的超磷酸化形式，剪接因子SC-35和p110 PITSLRE细胞周期蛋白依赖性激酶。因此，不同类型的神经元刺激可通过改变ania-6的转录和剪接来差异调节核RNA的加工。

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《Neuron》 |2001年第2期|共11页
作者
Berke JD; Sgambato V; Zhu PP; Lavoie B; Vincent M; Krause M; Hyman SE;
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正文语种 eng
中图分类神经生理学;
关键词
Alternative Splicing; Corpus Striatum; Cyclins; Dopamine; Glutamic Acid; 交替剪接; 纹状体; 细胞周期蛋白类; 多巴胺; 谷氨酸; RNA聚合酶Ⅱ;

机译：Alternative Splicing;Corpus Striatum;Cyclins;Dopamine;Glutamic Acid;交替剪接;纹状体;细胞周期蛋白类;多巴胺;谷氨酸;RNA聚合酶Ⅱ;

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1. Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin. [J] . Berke JD, Sgambato V, Zhu PP, Neuron . 2001,第2期

机译：多巴胺和谷氨酸诱导不同的纹状体剪接形式的Ania-6（一种与RNA聚合酶II相关的细胞周期蛋白）。
2. Prefrontal cortical-striatal dopamine receptor mRNA expression predicts distinct forms of impulsivity [J] . SimonN.W., BeasB.S., MontgomeryK.S., The European Journal of Neuroscience . 2013,第11a12期

机译：前额叶皮层纹状体多巴胺受体mRNA表达预测冲动的不同形式
3. Apomorphine-induced alterations in striatal and substantia nigra pars reticulata glutamate following unilateral loss of striatal dopamine. [J] . Touchon JC, Holmer HK, Moore C, Experimental Neurology . 2005,第1期

机译：单侧损失纹状体多巴胺后，阿扑吗啡诱导的纹状体和黑质网状谷氨酸的改变。
4. Regulation of Dopamine Release by Striatal Acetylcholine and Nicotine Is via Distinct Nicotinic Acetylcholine Receptors in Dorsal vs. Ventral Striatum [C] . Richard Exley, Michael A. Clements, Stephanie J. Cragg Triennial Meeting of the International Basal Ganglia Society . 2009

机译：通过纹状体乙酰胆碱和尼古丁对多巴胺释放的调节是通过不同的烟碱乙酰胆碱受体在背侧与腹侧纹状体中
5. A complex program of dopamine-induced gene expression identified using differential-display PCR: Discovery of a novel inducible cyclin. [D] . Berke, Joshua Damien. 1998

机译：使用差异显示PCR鉴定的多巴胺诱导的基因表达的复杂程序：发现新型诱导型细胞周期蛋白。
6. Withdrawal: Cyclin L2 a novel RNA polymerase II-associated cyclinis involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinomacells [O] . Lianjun Yang, Nan Li, Chunmei Wang, 2021

机译：戒断：细胞周期蛋白L2新型RNA聚合酶II相关的细胞周期蛋白参与前mRNA剪接并诱导人肝细胞癌的凋亡细胞
7. Dopamine and Glutamate Induce Distinct Striatal Splice Forms of Ania-6, an RNA Polymerase II-Associated Cyclin [O] . Berke Joshua D., Sgambato Véronique, Zhu Peng-Peng, 2001

机译：多巴胺和谷氨酸诱导不同的纹状体剪接形式的Ania-6，RNA聚合酶II相关的细胞周期蛋白。

Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin.

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