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首页> 外文期刊>Neuron >Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex.
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Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex.

机译：大鼠体感皮层总血红蛋白浓度，氧合和神经活动的耦合。

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摘要

Recent advances in brain imaging techniques, including functional magnetic resonance imaging (fMRI), offer great promise for noninvasive mapping of brain function. However, the indirect nature of the imaging signals to the underlying neural activity limits the interpretation of the resulting maps. The present report represents the first systematic study with sufficient statistical power to quantitatively characterize the relationship between changes in blood oxygen content and the neural spiking and synaptic activity. Using two-dimensional optical measurements of hemodynamic signals, simultaneous recordings of neural activity, and an event-related stimulus paradigm, we demonstrate that (1) there is a strongly nonlinear relationship between electrophysiological measures of neuronal activity and the hemodynamic response, (2) the hemodynamic response continues to grow beyond the saturation of electrical activity, and (3) the initial increase in deoxyhemoglobin that precedes an increase in blood volume is counterbalanced by an equal initial decrease in oxyhemoglobin.
机译：脑部成像技术（包括功能磁共振成像（fMRI））的最新进展为脑部功能的非侵入性测绘提供了广阔的前景。但是，成像信号对潜在神经活动的间接性质限制了对结果图的解释。本报告是第一个系统的研究，具有足够的统计能力来定量表征血氧含量变化与神经突增和突触活动之间的关系。使用血液动力学信号的二维光学测量，神经活动的同时记录以及与事件相关的刺激范例，我们证明（1）神经元活动的电生理测量与血液动力学反应之间存在强烈的非线性关系，（2）血流动力学反应继续增长，超过电活动的饱和度;（3）血红蛋白水平的相等初始下降抵消了血容量增加之前的脱氧血红蛋白的初始增加。

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