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首页> 外文期刊>Neuron >A cellular mechanism for prepulse inhibition.
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A cellular mechanism for prepulse inhibition.

机译:前脉冲抑制的细胞机制。

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摘要

In prepulse inhibition (PPI), startle responses to sudden, unexpected stimuli are markedly attenuated if immediately preceded by a weak stimulus of almost any modality. This experimental paradigm exposes a potent inhibitory process, present in nervous systems from invertebrates to humans, that is widely considered to play an important role in reducing distraction during the processing of sensory input. The neural mechanisms mediating PPI are of considerable interest given evidence linking PPI deficits with some of the cognitive disorders of schizophrenia. Here, in the marine mollusk Tritonia diomedea, we describe a detailed cellular mechanism for PPI-a combination of presynaptic inhibition of startle afferent neurons together with distributed postsynaptic inhibition of several downstream interneuronal sites in the startle circuit.
机译:在脉冲前抑制(PPI)中,如果立即在几乎任何形式的微弱刺激之后立即显着减弱对突然的意外刺激的惊吓反应。这种实验范式揭示了从无脊椎动物到人的神经系统中存在的有效抑制过程,该过程被广泛认为在减少感觉输入过程中的注意力分散方面起着重要作用。鉴于有证据表明PPI缺乏与精神分裂症的某些认知障碍相关,因此介导PPI的神经机制引起了极大的兴趣。在这里,在海洋软体动物Tritonia diomedea中,我们描述了PPI的详细细胞机制-惊吓传入神经元的突触前抑制与惊吓回路中几个下游神经元间位点的分布式突触后抑制的组合。

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