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首页> 外文期刊>Neuron >Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior.
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Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior.

机译：下丘脑中的分解活性神经元：对组胺在睡眠和清醒行为中的作用的影响。

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Noradrenergic, serotonergic, and histaminergic neurons are continuously active during waking, reduce discharge during NREM sleep, and cease discharge during REM sleep. Cataplexy, a symptom associated with narcolepsy, is a waking state in which muscle tone is lost, as it is in REM sleep, while environmental awareness continues, as in alert waking. In prior work, we reported that, during cataplexy, noradrenergic neurons cease discharge, and serotonergic neurons greatly reduce activity. We now report that, in contrast to these other monoaminergic "REM-off" cell groups, histamine neurons are active in cataplexy at a level similar to or greater than that in quiet waking. We hypothesize that the activity of histamine cells is linked to the maintenance of waking, in contrast to activity in noradrenergic and serotonergic neurons, which is more tightly coupled to the maintenance of muscle tone in waking and its loss in REM sleep and cataplexy.
机译：醒来时，去甲肾上腺素能，血清素能和组胺能神经元持续活跃，在NREM睡眠期间减少放电，并在REM睡眠期间停止放电。 Cataplexy是一种与发作性睡病相关的症状，是一种醒来状态，在这种状态下，肌肉的音调丧失（如在REM睡眠中），而环境意识仍在持续（如警觉清醒）。在先前的工作中，我们报道了在脑瘫期间，去甲肾上腺素能神经元停止放电，而血清素能神经元大大降低了活动。我们现在报道，与这些其他单胺能性“ REM-off”细胞群相反，组胺神经元在白细胞复合症中的活性水平类似于或大于安静唤醒中的水平。我们假设组胺细胞的活性与清醒的维持有关，与去甲肾上腺素能和血清素能神经元的活性相反，后者与清醒时的肌肉张力维持及其在REM睡眠和瘫痪中的丧失紧密相关。

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