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首页> 外文期刊>Neuron >Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology.
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Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology.

机译：脑疾病中的神经同步性：与认知功能障碍和病理生理的相关性。

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Following the discovery of context-dependent synchronization of oscillatory neuronal responses in the visual system, novel methods of time series analysis have been developed for the examination of task- and performance-related oscillatory activity and its synchronization. Studies employing these advanced techniques revealed that synchronization of oscillatory responses in the beta- and gamma-band is involved in a variety of cognitive functions, such as perceptual grouping, attention-dependent stimulus selection, routing of signals across distributed cortical networks, sensory-motor integration, working memory, and perceptual awareness. Here, we review evidence that certain brain disorders, such as schizophrenia, epilepsy, autism, Alzheimer's disease, and Parkinson's are associated with abnormal neural synchronization. The data suggest close correlations between abnormalities in neuronal synchronization and cognitive dysfunctions, emphasizing the importance of temporal coordination. Thus, focused search for abnormalities in temporal patterning may be of considerable clinical relevance.
机译：在视觉系统中发现振动神经元响应的上下文相关同步之后，开发了时间序列分析的新方法来检查与任务和性能相关的振荡活动及其同步。采用这些先进技术的研究表明，β和γ波段振荡响应的同步涉及多种认知功能，例如知觉分组，注意力依赖的刺激选择，跨分布式皮层网络的信号路由，感觉运动整合，工作记忆和感知意识。在这里，我们回顾了某些脑部疾病的证据，例如精神分裂症，癫痫症，自闭症，阿尔茨海默氏病和帕金森氏症与异常的神经同步性有关。数据表明神经元同步异常与认知功能障碍之间密切相关，强调了时间协调的重要性。因此，针对时间模式异常进行集中搜索可能具有相当大的临床意义。

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