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首页> 外文期刊>Neuron >Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions.
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Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions.

机译：Semaphorin-1a / PlexinA介导的轴突-轴突相互作用对嗅觉受体神经元的时间目标限制。

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Axon-axon interactions have been implicated in neural circuit assembly, but the underlying mechanisms are poorly understood. Here, we show that in the Drosophila antennal lobe, early-arriving axons of olfactory receptor neurons (ORNs) from the antenna are required for the proper targeting of late-arriving ORN axons from the maxillary palp (MP). Semaphorin-1a is required for targeting of all MP but only half of the antennal ORN classes examined. Sema-1a acts nonautonomously to control ORN axon-axon interactions, in contrast to its cell-autonomous function in olfactory projection neurons. Phenotypic and genetic interaction analyses implicate PlexinA as the Sema-1a receptor in ORN targeting. Sema-1a on antennal ORN axons is required for correct targeting of MP axons within the antennal lobe, while interactions amongst MP axons facilitate their entry into the antennal lobe. We propose that Sema-1a/PlexinA-mediated repulsion provides a mechanism by which early-arriving ORN axons constrain the target choicesof late-arriving axons.
机译：轴突-轴突相互作用已牵涉到神经回路组装，但基本的机制了解甚少。在这里，我们表明，在果蝇触角叶中，嗅觉受体神经元（ORN）的早到达轴突是从上颚pa（MP）到晚到达的ORN轴突的正确目标所必需的。 Semaphorin-1a可用于靶向所有MP，但仅需检测一半的触角ORN类。与嗅觉投射神经元的细胞自主功能相反，Sema-1a非自主地控制ORN轴突-轴突相互作用。表型和遗传相互作用分析暗示PlexinA作为ORN靶向中的Sema-1a受体。正确定位触角叶内的MP轴突需要触角ORN轴突上的Sema-1a，而MP轴突之间的相互作用有助于它们进入触角叶。我们建议Sema-1a / PlexinA介导的排斥提供了一种机制，通过该机制，早期到达的ORN轴突限制了晚期到达的轴突的目标选择。

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