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首页> 外文期刊>Neuron >Depolarization redistributes synaptic membrane and creates a gradient of vesicles on the synaptic body at a ribbon synapse.
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Depolarization redistributes synaptic membrane and creates a gradient of vesicles on the synaptic body at a ribbon synapse.

机译：去极化使突触膜重新分布，并在带状突触处在突触体上形成囊泡梯度。

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摘要

We used electron tomography of frog saccular hair cells to reconstruct presynaptic ultrastructure at synapses specialized for sustained transmitter release. Synaptic vesicles at inhibited synapses were abundant in the cytoplasm and covered the synaptic body at high density. Continuous maximal stimulation depleted 73% of the vesicles within 800 nm of the synapse, with a concomitant increase in surface area of intracellular cisterns and plasmalemmal infoldings. Docked vesicles were depleted 60%-80% regardless of their distance from the active zone. Vesicles on the synaptic body were depleted primarily in the hemisphere facing the plasmalemma, creating a gradient of vesicles on its surface. We conclude that formation of new synaptic vesicles from cisterns is rate limiting in the vesicle cycle.
机译：我们使用了青蛙的囊状毛细胞的电子断层扫描技术来重建突触前的突触前超微结构，专门用于持续释放递质。抑制突触的突触小泡在细胞质中丰富，并以高密度覆盖突触体。连续最大刺激耗尽了突触800 nm内的73％的囊泡，并伴随着细胞内蓄水池表面积的增加和质膜折叠。停靠的囊泡耗尽了60％-80％，无论它们与活动区域的距离如何。突触体上的囊泡主要在面对质膜的半球被消耗掉，在其表面上形成了梯度的囊泡。我们得出结论，从水箱中形成新的突触囊泡是囊泡周期中的速率限制。

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