Intracellular Ca2+ signaling and human disease: the hunt begins with Huntington's.

Varshney A; Ehrlich BE

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Intracellular Ca2+ signaling and human disease: the hunt begins with Huntington's.

机译：细胞内Ca2 +信号传导和人类疾病：狩猎始于亨廷顿舞蹈症。

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Huntingtin, a protein altered by polyglutamine expansion in Huntington's disease (Httexp), forms a signaling complex with the InsP3R, an intracellular calcium channel, and Htt-associated protein 1A (HAP1A). The addition of Httexp increases the InsP3R sensitivity to InsP3, which subsequently makes neurons hyperresponsive to stimulation and presumably more prone to neurodegenerative processes.

机译：亨廷顿蛋白是一种在亨廷顿舞蹈病（Httexp）中被多聚谷氨酰胺膨胀改变的蛋白质，它与InsP3R，细胞内钙通道和Htt相关蛋白1A（HAP1A）形成信号复合物。 Httexp的添加增加了InsP3R对InsP3的敏感性，随后使神经元对刺激反应过度，并可能更倾向于神经退行性过程。

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《Neuron》 |2003年第2期|共3页
作者
Varshney A; Ehrlich BE;
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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Calcium; Calcium Signaling; Huntington Disease metabolism; 钙; 钙信号;

机译：Calcium;Calcium Signaling;Huntington Disease metabolism;钙;钙信号;

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1. Intracellular Ca2+ signaling and human disease: the hunt begins with Huntington's. [J] . Varshney A, Ehrlich BE Neuron . 2003,第2期

机译：细胞内Ca2 +信号传导和人类疾病：狩猎始于亨廷顿舞蹈症。
2. Contribution of intracellular Ca2+ stores to Ca2+ signaling during chemokinesis of human neutrophil granulocytes. [J] . Baron S, Struyf S, Wuytack F Biochimica et biophysica acta. Molecular cell research . 2009,第6期

机译：人类嗜中性粒细胞趋化过程中细胞内Ca2 +储存对Ca2 +信号传导的贡献。
3. Altered Ca2+ signaling in skeletal muscle fibers of the R6/2 mouse, a model of Huntington’s disease [J] . Peter Braubach, Murat Orynbayev, Zoita Andronache, The Journal of general physiology . 2014,第5期

机译：R6 / 2小鼠（亨廷顿舞蹈病的模型）的骨骼肌纤维中的Ca2 +信号改变
4. Impact of the steady state IP3 level on the intracellular Ca2+ signaling in spatially distributed model of astrocyte [C] . Innokentiy Kastalskiy, Anastasia Ermolaeva, Victor Kazantsev, Conference on Scientific School on Dynamics of Complex Networks and their Application in Intellectual Robotics . 2020

机译：星形胶质细胞空间分布模型中稳态IP3水平对细胞内Ca2 +信号传导的影响
5. Intracellular Signal Transduction Mechanisms Regulating the Activation of Human Bronchial Epithelial Cells by Interleukin-17A, Interleukin-27, Tumor Necrosis Factor-alpha and Human Basophils in Inflammatory Diseases [D] . Cao, Ju 2010

机译：调节人白细胞介素17A，白细胞介素27，肿瘤坏死因子-α和人类嗜碱性粒细胞在炎性疾病中激活人支气管上皮细胞的细胞内信号转导机制
6. Altered Ca2+ signaling in skeletal muscle fibers of the R6/2 mouse a model of Huntington’s disease [O] . Peter Braubach, Murat Orynbayev, Zoita Andronache, 2014

机译：R6 / 2小鼠（亨廷顿舞蹈病的模型）的骨骼肌纤维中Ca2 +信号改变
7. Intracellular Ca2+ Signaling and Human Disease The Hunt Begins with Huntington's [O] . Varshney Anurag, Ehrlich Barbara E 2003

机译：细胞内Ca2 +信号传导与人类疾病狩猎始于亨廷顿舞蹈症

Intracellular Ca2+ signaling and human disease: the hunt begins with Huntington's.

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