...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Calmodulin-kinases: modulators of neuronal development and plasticity.
【24h】

Calmodulin-kinases: modulators of neuronal development and plasticity.

机译：钙调蛋白激酶：神经元发育和可塑性的调节剂。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the nervous system, many intracellular responses to elevated calcium are mediated by CaM kinases (CaMKs), a family of protein kinases whose activities are initially modulated by binding Ca(2+)/calmodulin and subsequently by protein phosphorylation. One member of this family, CaMKII, is well-established for its effects on modulating synaptic plasticity and learning and memory. However, recent studies indicate that some actions on neuronal development and function attributed to CaMKII may instead or in addition be mediated by other members of the CaMK cascade, such as CaMKK, CaMKI, and CaMKIV. This review summarizes key neuronal functions of the CaMK cascade in signal transduction, gene transcription, synaptic development and plasticity, and behavior. The technical challenges of mapping cellular protein kinase signaling pathways are also discussed.
机译：在神经系统中，对钙离子升高的许多细胞内反应均由CaM激酶（CaMK）介导，CaM激酶是一类蛋白激酶，其活性最初是通过结合Ca（2 +）/钙调蛋白而随后通过蛋白磷酸化来调节的。该家族的一个成员，CaMKII，因其对调节突触可塑性和学习记忆的作用而广为人知。但是，最近的研究表明，归因于CaMKII的神经元发育和功能的某些动作可能替代或另外由CaMK级联的其他成员（例如CaMKK，CaMKI和CaMKIV）介导。这篇综述总结了CaMK级联在信号转导，基因转录，突触发展和可塑性以及行为方面的关键神经元功能。还讨论了映射细胞蛋白激酶信号传导途径的技术挑战。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号