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首页> 外文期刊>Neuron >Two different forms of arousal in Drosophila are oppositely regulated by the dopamine D1 receptor ortholog DopR via distinct neural circuits.
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Two different forms of arousal in Drosophila are oppositely regulated by the dopamine D1 receptor ortholog DopR via distinct neural circuits.

机译：果蝇中两种不同的唤醒方式是通过多巴胺D1受体直系同源物DopR通过不同的神经回路相反地调节的。

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摘要

Arousal is fundamental to many behaviors, but whether it is unitary or whether there are different types of behavior-specific arousal has not been clear. In Drosophila, dopamine promotes sleep-wake arousal. However, there is conflicting evidence regarding its influence on environmentally stimulated arousal. Here we show that loss-of-function mutations in the D1 dopamine receptor DopR enhance repetitive startle-induced arousal while decreasing sleep-wake arousal (i.e., increasing sleep). These two types of arousal are also inversely influenced by cocaine, whose effects in each case are opposite to, and abrogated by, the DopR mutation. Selective restoration of DopR function in the central complex rescues the enhanced stimulated arousal but not the increased sleep phenotype of DopR mutants. These data provide evidence for at least two different forms of arousal, which are independently regulated by dopamine in opposite directions, via distinct neural circuits.
机译：唤醒是许多行为的基础，但尚不清楚是统一的还是特定于行为的唤醒类型。在果蝇中，多巴胺可促进觉醒觉醒。但是，关于其对环境刺激唤醒的影响，有相互矛盾的证据。在这里，我们表明D1多巴胺受体DopR中的功能丧失突变增强了重复的惊吓诱发的唤醒，同时减少了睡眠-觉醒的唤醒（即增加睡眠）。这两种类型的唤醒也受到可卡因的反作用，可卡因在每种情况下的作用都与DopR突变相反，并被DopR突变所消除。在中枢复合物中选择性恢复DopR功能可以挽救增强的刺激觉醒，但不能挽救DopR突变体的睡眠表型。这些数据提供了至少两种不同形式的唤醒的证据，它们通过不同的神经回路由多巴胺沿相反的方向独立调节。

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