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Topography of Place Maps along the CA3-to-CA2 Axis of the Hippocampus

机译：沿海马CA3-to-CA2轴放置地图的地形

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We asked whether the structural heterogeneity of the hippocampal CA3-CA2 axis is reflected in how space is mapped onto place cells in CA3-CA2. Place fields were smaller and sharper in proximal CA3 than in distal CA3 and CA2. The proximodistal shift was accompanied by a progressive loss in the ability of place cells to distinguish configurations of the same spatial environment, as well as a reduction in the extent to which place cells formed uncorrelated representations for different environments. The transition to similar representations was nonlinear, with the sharpest drop in distal CA3. These functional changes along the CA3-CA2 axis mirror gradients in gene expression and connectivity that partly override cytoarchitectonic boundaries between the subfields of the hippocampus. The results point to the CA3-CA2 axis as a functionally graded system with powerful pattern separation at the proximal end, near the dentate gyrus, and stronger pattern completion at the CA2 end.
机译：我们询问海马CA3-CA2轴的结构异质性是否反映在如何将空间映射到CA3-CA2中的位置细胞上。与近端CA3和CA2相比，近端CA3中的放置区域更小且更清晰。前近移伴随着位置细胞区分相同空间环境的配置的能力的逐渐丧失，以及位置细胞形成不同环境的不相关表示的程度降低。向相似图示的过渡是非线性的，远端CA3下降最为明显。这些沿CA3-CA2轴的功能变化反映了基因表达和连通性中的梯度，从而部分覆盖了海马亚区之间的细胞构建边界。结果表明，CA3-CA2轴是功能分级的系统，在齿状回附近的近端具有强大的图案分离功能，在CA2端具有更强的图案完成度。

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