Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase.

Garrity PA; Lee CH; Salecker I; Robertson HC; Desai CJ; Zinn K; Zipursky SL

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Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase.

机译：果蝇中视网膜轴突靶标的选择受受体蛋白酪氨酸磷酸酶的调节。

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Different Drosophila photoreceptors (R cells) connect to neurons in different optic lobe layers. R1-R6 axons project to the lamina; R7 and R8 axons project to separate layers of the medulla. We show a receptor tyrosine phosphatase, PTP69D, is required for lamina target specificity. In Ptp69D mutants, R1-R6 project through the lamina, terminating in the medulla. Genetic mosaics, transgene rescue, and immunolocalization indicate PTP69D functions in R1-R6 growth cones. PTP69D overexpression in R7 and R8 does not respecify their connections, suggesting PTP69D acts in combination with other factors to determine target specificity. Structure-function analysis indicates the extracellular fibronectin type III domains and intracellular phosphatase activity are required for targeting. We propose PTP69D promotes R1-R6 targeting in response to extracellular signals by dephosphorylating substrate(s) in R1-R6 growth cones.

机译：不同的果蝇感光细胞（R细胞）连接到不同视神经叶层的神经元。 R1-R6轴突伸向椎板; R7和R8轴突投射到分离的髓质层。我们显示受体酪氨酸磷酸酶，PTP69D，对于椎板目标特异性是必需的。在Ptp69D突变体中，R1-R6穿过椎板，终止于延髓。遗传镶嵌，转基因抢救和免疫定位表明PTP69D在R1-R6生长锥中的功能。 R7和R8中的PTP69D过表达并未重新指定它们的连接，这表明PTP69D与其他因素共同作用来确定靶标特异性。结构功能分析表明，胞外纤连蛋白III型结构域和胞内磷酸酶活性是靶向所需的。我们提出PTP69D通过使R1-R6生长锥中的底物去磷酸化来响应细胞外信号而促进R1-R6靶向。

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《Neuron》 |1999年第4期|共11页
作者
Garrity PA; Lee CH; Salecker I; Robertson HC; Desai CJ; Zinn K; Zipursky SL;
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正文语种 eng
中图分类神经生理学;
关键词
Drosophila; Protein-Tyrosine-Phosphatase; 果蝇属;

机译：Drosophila;Protein-Tyrosine-Phosphatase;果蝇属;

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1. 蛋白酪氨酸磷酸酶1B在视网膜疾病中的研究进展 [J] . 刘聪眼科学报（英文版） . 2020,第003期
2. Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase. [J] . Garrity PA, Lee CH, Salecker I, Neuron . 1999,第4期

机译：果蝇中视网膜轴突靶标的选择受受体蛋白酪氨酸磷酸酶的调节。
3. The receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila [J] . Song JK, Desai CJ Mechanisms of Development . 2008,第3a4期

机译：受体蛋白酪氨酸磷酸酶PTP69D拮抗Abl酪氨酸激酶以指导果蝇中的轴突。
4. Hindsight regulates photoreceptor axon targeting through transcriptional control of jitterbug/Filamin and multiple genes involved in axon guidance in Drosophila [J] . Oliva Carlos, Molina-Fernandez Claudia, Maureira Miguel, Developmental neurobiology . 2015,第9期

机译：Hindsight通过对Jitterbug / Filamin的转录控制以及果蝇中轴突指导中涉及的多个基因的转录控制来调节光感受器轴突的靶向作用。
5. MICROGRAVITY AND SIGNALING MOLECULES IN RAT OSTEOBLASTS: DOWNSTREAM OF RECEPTOR TYROSINE KINASE, G-PROTEIN-COUPLED RECEPTOR, AND SMALL GTP-BINDING PROTEINS [C] . Yasuhiro Kumei, Hitoyata Shimokawa, Sadao Morita, European Symposium on Life Sciences in Space . 2005

机译：大鼠成骨细胞中的微匍匐和信号分子：受体酪氨酸激酶，G蛋白偶联受体和小GTP结合蛋白的下游
6. The receptor protein tyrosine phosphatase-mu signaling pathway differentially regulates E-cadherin, N-cadherin and R-cadherin-mediated axon outgrowth. [D] . Oblander, Samantha Anne. 2009

机译：受体蛋白酪氨酸磷酸酶-mu信号转导通路差异调节E-钙粘蛋白，N-钙粘蛋白和R-钙粘蛋白介导的轴突生长。
7. The Receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila [O] . Jeong K. Song, Edward Giniger, Chand J. Desai -1

机译：受体蛋白酪氨酸磷酸酶PTP69D拮抗Abl酪氨酸激酶以指导果蝇中的轴突。
8. Retinal Axon Target Selection in Drosophila Is Regulated by a Receptor Protein Tyrosine Phosphatase [O] . Garrity Paul A., Lee Chi-Hon, Salecker Iris, 1999

机译：果蝇中的视网膜轴突靶标选择受受体蛋白酪氨酸磷酸酶的调节。

Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase.

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