...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Increased noise level of purkinje cell activities minimizes impact of their modulation during sensorimotor control.
【24h】

Increased noise level of purkinje cell activities minimizes impact of their modulation during sensorimotor control.

机译：浦肯野细胞活动的噪声水平提高，从而在感觉运动控制过程中将其调制的影响降至最低。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

While firing rate is well established as a relevant parameter for encoding information exchanged between neurons, the significance of other parameters is more conjectural. Here, we show that regularity of neuronal spike activities affects sensorimotor processing in tottering mutants, which suffer from a mutation in P/Q-type voltage-gated calcium channels. While the modulation amplitude of the simple spike firing rate of their floccular Purkinje cells during optokinetic stimulation is indistinguishable from that of wild-types, the regularity of their firing is markedly disrupted. The gain and phase values of tottering's compensatory eye movements are indistinguishable from those of flocculectomized wild-types or from totterings with the flocculus treated with P/Q-type calcium channel blockers. Moreover, normal eye movements can be evoked in tottering when the flocculus is electrically stimulated with regular spike trains mimicking the firing pattern of normal simple spikes. This study demonstrates the importance of regularity of firing in Purkinje cells for neuronal information processing.
机译：虽然发射率已被很好地确立为用于编码神经元之间交换信息的相关参数，但其他参数的意义却更具推测性。在这里，我们表明神经元尖峰活动的规律性会影响蹒跚的突变体中的感觉运动过程，这些突变体遭受P / Q型电压门控钙通道的突变。尽管在光动力刺激期间它们的絮状浦肯野细胞的简单尖峰发射速率的调制幅度与野生型没有区别，但是它们的发射规律被明显破坏。蹒跚的补偿性眼球运动的增益和相位值与经絮凝切除的野生型和经P / Q型钙通道阻滞剂处理的絮凝物的颤振的增益和相位值没有区别。此外，当用规则的尖峰脉冲串模拟正常简单尖峰脉冲的发射方式来电刺激絮状物时，通常会在eye叫中引起正常的眼球运动。这项研究证明了浦肯野细胞中放电规律性对于神经元信息处理的重要性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号