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首页> 外文期刊>Neuron >Mapping cortical activity elicited with electrical microstimulation using FMRI in the macaque.
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Mapping cortical activity elicited with electrical microstimulation using FMRI in the macaque.

机译：在猕猴中使用FMRI通过电微刺激诱发皮层活动的定位。

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Over the last two centuries, electrical microstimulation has been used to demonstrate causal links between neural activity and specific behaviors and cognitive functions. However, to establish these links it is imperative to characterize the cortical activity patterns that are elicited by stimulation locally around the electrode and in other functionally connected areas. We have developed a technique to record brain activity using the blood oxygen level dependent (BOLD) signal while applying electrical microstimulation to the primate brain. We find that the spread of activity around the electrode tip in macaque area V1 was larger than expected from calculations based on passive spread of current and therefore may reflect functional spread by way of horizontal connections. Consistent with this functional transynaptic spread we also obtained activation in expected projection sites in extrastriate visual areas, demonstrating the utility of our technique in uncovering in vivo functional connectivity maps.
机译：在过去的两个世纪中，电微刺激已被用于证明神经活动与特定行为和认知功能之间的因果关系。但是，要建立这些链接，必须表征由电极周围和其他功能连接区域中的局部刺激引起的皮层活动模式。我们已经开发了一种技术，该技术使用血氧水平依赖性（BOLD）信号记录大脑活动，同时对灵长类动物大脑进行电微刺激。我们发现猕猴区V1中电极尖端周围的活性分布大于根据基于电流的被动分布的计算所预期的范围，因此可以反映通过水平连接的功能分布。与这种功能性突触传播相一致，我们还获得了在超视域中预期的投影部位的激活，这证明了我们的技术在揭示体内功能连接图方面的效用。

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