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首页> 外文期刊>Neuron >Response features of parvalbumin-expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex.
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Response features of parvalbumin-expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex.

机译：表达小白蛋白的中间神经元的反应特征表明视觉皮层抑制亚型的确切作用。

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Inhibitory interneurons in the cerebral cortex include a vast array of subtypes, varying in their molecular signatures, electrophysiological properties, and connectivity patterns. This diversity suggests that individual inhibitory classes have unique roles in cortical circuits; however, their characterization to date has been limited to broad classifications including many subtypes. We used the Cre/LoxP system, specifically labeling parvalbumin(PV)-expressing interneurons in visual cortex of PV-Cre mice with red fluorescent protein (RFP), followed by targeted loose-patch recordings and two-photon imaging of calcium responses in vivo to characterize the visual receptive field properties of these cells. Despite their relative molecular and morphological homogeneity, we find that PV+ neurons have a diversity of feature-specific visual responses that include sharp orientation and direction-selectivity, small receptive fields, and band-pass spatial frequency tuning. These results suggest that subsets of parvalbumin interneurons are components of specific cortical networks and that perisomatic inhibition contributes to the generation of precise response properties.
机译：大脑皮层中的抑制性神经元包括大量亚型，它们的分子特征，电生理特性和连通性模式各不相同。这种多样性表明，单个抑制类在皮质回路中具有独特的作用。然而，迄今为止，它们的表征仅限于广泛的分类，包括许多亚型。我们使用Cre / LoxP系统，特别是在PV-Cre小鼠的视觉皮层中用红色荧光蛋白（RFP）标记表达小白蛋白（PV）的中间神经元，然后进行针对性的散斑记录和体内钙反应的双光子成像来表征这些细胞的视觉感受特性。尽管它们具有相对的分子和形态同质性，但我们发现PV +神经元具有特定于功能的视觉响应，包括敏锐的方向和方向选择性，小的接收场以及带通空间频率调谐。这些结果表明，小白蛋白中间神经元的子集是特定皮层网络的组成部分，而perisomatic抑制有助于产生精确的响应特性。

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