Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory.

Mazzucchelli C; Vantaggiato C; Ciamei A; Fasano S; Pakhotin P; Krezel W; Welzl H; Wolfer DP; Pages G; Valverde O; Marowsky A; Porrazzo A; Orban PC; Maldonado R; Ehrengruber MU; Cestari V; Lipp HP; Chapman PF; Pouyssegur J; Brambilla R

首页> 外文期刊>Neuron >Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory.

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Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory.

机译：ERK1 MAP激酶的敲除可增强纹状体中的突触可塑性，并促进纹状体介导的学习和记忆。

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Extracellular signal-regulated kinases (ERK1 and 2) are synaptic signaling components necessary for several forms of learning. In mice lacking ERK1, we observe a dramatic enhancement of striatum-dependent long-term memory, which correlates with a facilitation of long-term potentiation in the nucleus accumbens. At the cellular level, we find that ablation of ERK1 results in a stimulus-dependent increase of ERK2 signaling, likely due to its enhanced interaction with the upstream kinase MEK. Consistently, such activity change is responsible for the hypersensitivity of ERK1 mutant mice to the rewarding properties of morphine. Our results reveal an unexpected complexity of ERK-dependent signaling in the brain and a critical regulatory role for ERK1 in the long-term adaptive changes underlying striatum-dependent behavioral plasticity and drug addiction.

机译：细胞外信号调节激酶（ERK1和2）是几种学习形式所必需的突触信号传导成分。在缺少ERK1的小鼠中，我们观察到纹状体依赖的长期记忆显着增强，这与伏隔核的长期增强作用有关。在细胞水平，我们发现ERK1的消融导致ERK2信号转导的刺激依赖性增加，可能是由于其与上游激酶MEK的相互作用增强。一致地，这种活性的变化是造成ERK1突变小鼠对吗啡的奖励特性过敏的原因。我们的研究结果揭示了大脑中ERK依赖性信号的意想不到的复杂性，以及ERK1在纹状体依赖性行为可塑性和药物成瘾的长期适应性变化中的关键调节作用。

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《Neuron》 |2002年第5期|共14页
作者
Mazzucchelli C; Vantaggiato C; Ciamei A; Fasano S; Pakhotin P; Krezel W; Welzl H; Wolfer DP; Pages G; Valverde O; Marowsky A; Porrazzo A; Orban PC; Maldonado R; Ehrengruber MU; Cestari V; Lipp HP; Chapman PF; Pouyssegur J; Brambilla R;
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正文语种 eng
中图分类神经生理学;
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extracellular signal-regulated kinase 1; Learning; Memory observations; Mean arterial pressure; 学习; 磷酸转移酶类;

机译：extracellular signal-regulated kinase 1;Learning;Memory observations;Mean arterial pressure;学习;磷酸转移酶类;

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1. Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory. [J] . Mazzucchelli C, Vantaggiato C, Ciamei A, Neuron . 2002,第5期

机译：ERK1 MAP激酶的敲除可增强纹状体中的突触可塑性，并促进纹状体介导的学习和记忆。
2. Transgenic calmodulin-dependent protein kinase II activation: dose-dependent effects on synaptic plasticity, learning, and memory. [J] . Bejar R, Yasuda R, Krugers H, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2002,第13期

机译：转基因钙调蛋白依赖性蛋白激酶II激活：对突触可塑性，学习和记忆的剂量依赖性作用。
3. The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. [J] . Sweatt JD cm.tmc.edu Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2001,第1期

机译：神经元MAP激酶级联反应：维持突触可塑性和记忆力的生化信号整合系统。
4. Profiling global changes in the phosphoproteome of epithelial cells following the inhibition of ERK1/2 MAP kinase pathway [C] . COURCELLES M, VOISIN L, JULIEN C, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：抑制ERK1 / 2映射激酶途径后上皮细胞磷脂蛋白酶的谱分析全局变化
5. Beta calcium/calmodulin dependent kinase II and its role in synaptic plasticity, mammalian learning, and memory. [D] . Cho, Min H. 2007

机译：Beta钙/钙调蛋白依赖性激酶II及其在突触可塑性，哺乳动物学习和记忆中的作用。
6. Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II synaptic plasticity and spatial learning: A study with knockout mice [O] . Jhang Ho Pak, Freesia L. Huang, Junfa Li, 2000

机译：神经颗粒素参与调节钙/钙调蛋白依赖性蛋白激酶II突触可塑性和空间学习：剔除小鼠的研究
7. Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory [O] . Mazzucchelli Cristina, Vantaggiato Chiara, Ciamei Alessandro, 2002

机译：ERK1 MAP激酶的敲除增强纹状体中的突触可塑性，并促进纹状体介导的学习和记忆

Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory.

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