Presynaptic regulation of neurotransmission in Drosophila by the g protein-coupled receptor methuselah.

Song W; Ranjan R; Dawson Scully K; Bronk P; Marin L; Seroude L; Lin Y; Nie Z; Atwood H; Benzer S; Zinsmaier K

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Presynaptic regulation of neurotransmission in Drosophila by the g protein-coupled receptor methuselah.

机译：g蛋白偶联受体methuselah对果蝇神经传递的突触前调节。

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Regulation of synaptic strength is essential for neuronal information processing, but the molecular mechanisms that control changes in neuroexocytosis are only partially known. Here we show that the putative G protein-coupled receptor Methuselah (Mth) is required in the presynaptic motor neuron to acutely upregulate neurotransmitter exocytosis at larval Drosophila NMJs. Mutations in the mth gene reduce evoked neurotransmitter release by approximately 50%, and decrease synaptic area and the density of docked and clustered vesicles. Pre- but not postsynaptic expression of normal Mth restored normal release in mth mutants. Conditional expression of Mth restored normal release and normal vesicle docking and clustering but not the reduced size of synaptic sites, suggesting that Mth acutely adjusts vesicle trafficking to synaptic sites.

机译：突触强度的调节对于神经元信息处理至关重要，但是控制神经胞吐作用变化的分子机制仅是部分已知的。在这里，我们显示在突触前运动神经元中需要假定的G蛋白偶联受体Methuselah（Mth）来上调果蝇NMJ的神经递质胞吐作用。 mth基因中的突变使诱发的神经递质释放减少约50％，并降低突触面积和对接和成簇囊泡的密度。正常Mth的突触前表达但非突触后表达恢复了mth突变体的正常释放。 Mth的条件表达恢复正常释放和正常囊泡停泊和聚簇，但不能减小突触位点的大小，这表明Mth可以急性调节囊泡向突触位点的运输。

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《Neuron》 |2002年第1期|共1页
作者
Song W; Ranjan R; Dawson Scully K; Bronk P; Marin L; Seroude L; Lin Y; Nie Z; Atwood H; Benzer S; Zinsmaier K;
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正文语种 eng
中图分类神经生理学;
关键词
receptor; Drosophila; g lt; 3gt; Discharge (release); neurotransmission; 果蝇属;

机译：receptor;Drosophila;g 3;Discharge (release);neurotransmission;果蝇属;

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1. Presynaptic regulation of neurotransmission in Drosophila by the g protein-coupled receptor methuselah. [J] . Song W, Ranjan R, Dawson Scully K, Neuron . 2002,第1期

机译：g蛋白偶联受体methuselah对果蝇神经传递的突触前调节。
2. Extended Synaptotagmin Localizes to Presynaptic ER and Promotes Neurotransmission and Synaptic Growth in Drosophila [J] . Koto Kikuma, Xiling Li, Daniel Kim, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2017,第3期

机译：扩展的Synaptotagmin定位于突触前的ER，并促进果蝇的神经传递和突触生长。
3. Extended Synaptotagmin Localizes to Presynaptic ER and Promotes Neurotransmission and Synaptic Growth in Drosophila [J] . Kikuma Koto, Li Xiling, Kim Daniel, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2017,第3期

机译：扩展的SynaptoTagmin定位于突触前ER，并促进果蝇中的神经递血和突触生长
4. Computing the Maximum Using Presynaptic Inhibition with Glutamate Receptors [C] . Drazen Domijan, Mia Setic International Symposium on Advances in Brain, Vision, and Artificial Intelligence(BVAI 2007); 20071010-12; Naples(IT) . 2007

机译：使用谷氨酸受体的突触前抑制来计算最大值
5. Experience-dependent regulation of presynaptic NMDA receptors (preNMDARs) and their role in neurotransmission and synaptic plasticity. [D] . Corlew, Rebekah. 2009

机译：经验依赖的突触前NMDA受体（preNMDARs）的调节及其在神经传递和突触可塑性中的作用。
6. Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors [O] . Takanori Ida, Tomoko Takahashi, Hatsumi Tominaga, 2012

机译：果蝇中生物活性肽CCHamide-1和CCHamide-2的分离及其作为G蛋白偶联受体配体的食欲调节作用
7. Presynaptic Regulation of Neurotransmission in Drosophila by the G Protein-Coupled Receptor Methuselah [O] . Marder Et Al, A Complex, Seymour Benzer, 2015

机译：G蛋白偶联受体methuselah对果蝇神经传递的突触前调控

Presynaptic regulation of neurotransmission in Drosophila by the g protein-coupled receptor methuselah.

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