Targeted gene repair and its application to neurodegenerative disorders.

Parekh-Olmedo Hetal; Krainc Dimitri; Kmiec EricB

首页> 外文期刊>Neuron >Targeted gene repair and its application to neurodegenerative disorders.

【24h】

Targeted gene repair and its application to neurodegenerative disorders.

机译：靶向基因修复及其在神经退行性疾病中的应用。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Synthetic DNA oligonucleotides can direct the exchange of single nucleotides within coding regions of mammalian genes by hybridizing to their complementary sequence in the chromosome and creating a recombination joint structure with a single mismatched base pair. Inherent DNA repair processes recognize the mismatch and resolve it using the DNA sequence of the oligonucleotide vector as the template. This gene surgery approach can be used to repair mutations or to disrupt tri-nucleotide repeats in dysfunctional genes responsible for neurological disorders.

机译：合成的DNA寡核苷酸可通过与染色体中的互补序列杂交并创建具有单个错配碱基对的重组关节结构，来指导哺乳动物基因编码区内的单个核苷酸交换。固有的DNA修复过程可以识别错配并使用寡核苷酸载体的DNA序列作为模板来解决。这种基因手术方法可用于修复导致神经系统疾病的功能失调的基因中的突变或破坏三核苷酸重复。

著录项

来源
《Neuron》 |2002年第4期|共4页
作者
Parekh-Olmedo Hetal; Krainc Dimitri; Kmiec EricB;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经生理学;
关键词
Gene Targeting; Genetic Vectors; Mutation; Neurodegenerative Diseases; Oligonucleotide Probes; 基因靶效应; 遗传载体; 突变; 神经变性疾病; 寡核苷酸探针;

机译：Gene Targeting;Genetic Vectors;Mutation;Neurodegenerative Diseases;Oligonucleotide Probes;基因靶效应;遗传载体;突变;神经变性疾病;寡核苷酸探针;

相似文献

外文文献
中文文献
专利

1. Targeted gene repair and its application to neurodegenerative disorders. [J] . Parekh-Olmedo Hetal, Krainc Dimitri, Kmiec EricB Neuron . 2002,第4期

机译：靶向基因修复及其在神经退行性疾病中的应用。
2. After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders. [J] . Huber K, Superti Furga G Bioorganic and medicinal chemistry . 2011,第12期

机译：葡萄高峰后：sirtuins作为神经退行性疾病的表观遗传药物。
3. After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders. [J] . Huber K, Superti Furga G Bioorganic and medicinal chemistry . 2011,第12期

机译：葡萄高峰后：sirtuins作为神经退行性疾病的表观遗传药物。
4. Grape Seed Polyphenolic Extract as a Potential Therapeutic Compound in Tau-Mediated Neurodegenerative Disorders. Electron Microscopy Analysis of Paired Helical Filaments [C] . I. Santa-Maria Microscopy and microanalysis.;Microscopy and microanalysis. . -1

机译：葡萄籽多酚提取物作为Tau介导的神经退行性疾病的潜在治疗化合物。螺旋丝对的电子显微镜分析
5. Targeted gene repair of frameshift mutations: Insights into the mechanism and applications for gene therapy [D] . Maguire, Katie K. 2007

机译：移码突变的靶向基因修复：深入了解基因治疗的机制和应用
6. Targeted DNA methylation of neurodegenerative disease genes via homology directed repair [O] . Christopher P Cali, Daniel S Park, Edward B Lee 2019

机译：通过同源性定向修复的神经退行性疾病基因的靶向DNA甲基化
7. Targeted Gene Repair and Its Application to Neurodegenerative Disorders [O] . Parekh-Olmedo Hetal, Krainc Dimitri, Kmiec Eric B 2002

机译：靶向基因修复及其在神经退行性疾病中的应用
8. Drug Targets for the Treatment of Neurodegenerative Disorders. [R] . Muchowski, P. J. 2004

机译：用于治疗神经退行性疾病的药物靶点。

Targeted gene repair and its application to neurodegenerative disorders.

摘要

著录项

相似文献

相关主题

期刊订阅