Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.

Nelson AB; Gittis AH; du Lac S

首页> 外文期刊>Neuron >Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.

【24h】

Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.

机译：CaMKII活性的降低会触发自发激发前庭核神经元的内在兴奋性的持续增强。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Calcium/calmodulin-dependent protein kinase II (CaMKII) has been described as a biochemical switch that is turned on by increases in intracellular calcium to mediate synaptic plasticity. Here, we show that reductions in CaMKII activity trigger persistent increases in intrinsic excitability. In spontaneously firing vestibular nucleus neurons, CaMKII activity is near maximal, and blockade of CaMKII activity increases excitability by reducing BK-type calcium-activated potassium currents. Firing rate potentiation, a form of plasticity in which synaptic inhibition induces long-lasting increases in excitability, is occluded by prior blockade of CaMKII and blocked by addition of constitutively active CaMKII. Reductions in CaMKII activity are necessary and sufficient to induce firing rate potentiation and may contribute to motor learning in the vestibulo-ocular reflex.

机译：钙/钙调蛋白依赖性蛋白激酶II（CaMKII）被描述为一种生化开关，可通过增加细胞内钙来介导突触可塑性来开启。在这里，我们表明，CaMKII活性的降低会触发内在兴奋性的持续增加。在自发激发前庭核神经元中，CaMKII活性接近最大，并且通过降低BK型钙激活的钾电流，CaMKII活性的阻断增加了兴奋性。点火速率增强是可塑性的一种形式，其中突触抑制引起兴奋性的持久性提高，但由于事先阻断了CaMKII而被阻断，而加入了组成型活性CaMKII则阻止了这种作用。 CaMKII活性的降低是必要的，并且足以诱导射击频率增强，并且可能有助于前庭眼反射的运动学习。

著录项

来源
《Neuron》 |2005年第4期|共9页
作者
Nelson AB; Gittis AH; du Lac S;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Action Potentials; Ca(2+)-Calmodulin Dependent Protein Kinase; Neural Inhibition; 动作电位; 神经抑制; 神经元; 前庭神经核;

机译：Action Potentials;Ca(2+)-Calmodulin Dependent Protein Kinase;Neural Inhibition;动作电位;神经抑制;神经元;前庭神经核;

相似文献

外文文献
中文文献
专利

1. Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons. [J] . Nelson AB, Gittis AH, du Lac S Neuron . 2005,第4期

机译：CaMKII活性的降低会触发自发激发前庭核神经元的内在兴奋性的持续增强。
2. Intrinsic firing dynamics of vestibular nucleus neurons. [J] . Sekirnjak C, du Lac S The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2002,第6期

机译：前庭核神经元的内在放电动力学。
3. Relationship between afterhyperpolarization profiles and the regularity of spontaneous firings in rat medial vestibular nucleus neurons. [J] . Saito Y, Takazawa T, Ozawa S The European Journal of Neuroscience . 2008,第2期

机译：大鼠前庭内侧核神经元的超极化后分布与自发放电规律之间的关系。
4. Interpolative Frequency Characteristics Generators for the Vestibular Nucleus Activity [C] . Alexandru Codrean, Vlad Ceregan, Toma-Leonida Dragomir, International MultiConference of Engineers and Computer Scientists . 2010

机译：用于前庭核心活动的内插频率特性发生器
5. The GABAA receptor is a critical part of the sensing machinery that triggers homeostatic plasticity of synaptic strength and intrinsic excitability. [D] . Wilhelm, Jennifer Caldwell. 2008

机译：GABAA受体是传感机制的关键部分，可触发突触强度和内在兴奋性的稳态可塑性。
6. Protracted Withdrawal from Alcohol and Drugs of Abuse Impairs Long-Term Potentiation of Intrinsic Excitability in the Juxtacapsular Bed Nucleus of the Stria Terminalis [O] . Walter Francesconi, Fulvia Berton, Vez Repunte-Canonigo, 2009

机译：长期戒酒和滥用药物会损害纹状体纹状体近端床核的内在兴奋性的长期增强作用。
7. Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons. [O] . Nelson, Alexandra B., Gittis, Aryn H., du Lac, Sascha 2005

机译：CaMKII活性的下降会触发自发激发前庭核神经元的内在兴奋性的持续增强。
8. Persistent Increase of Hippocampal Presynaptic Axon Excitability After RepetitiveElectrical Stimulation: Dependence on N-Methyl-D-Aspartate Receptor Activity, Nitric-Oxide Synthase, and Temperature, (Quantal Analysts/Long-Term Potentiation/Neurophysiology [R] . McNaughton, B. L., Shen, J., Rao, G., 1994

机译：海马突触前轴突兴奋性持续上升RepetitiveElectrical刺激后：依赖是N-甲基d天冬氨酸受体活性，一氧化氮合酶，和温度（量子理论分析/长时程增强/神经生理学

Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons.

摘要

著录项

相似文献

相关主题

期刊订阅