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首页> 外文期刊>Neuron >Associative short-term synaptic plasticity mediated by endocannabinoids.
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Associative short-term synaptic plasticity mediated by endocannabinoids.

机译：内源性大麻素介导的短期联合突触可塑性。

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摘要

Associative learning is important on rapid timescales, but no suitable form of short-term plasticity has been identified that is both associative and synapse specific. Here, we assess whether endocannabinoids can mediate such plasticity. In the cerebellum, bursts of parallel fiber (PF) activity evoke endocannabinoid release from Purkinje cell dendrites that results in retrograde synaptic inhibition lasting seconds. We find that the powerful climbing fiber (CF) to Purkinje cell synapse regulates this inhibition. Compared to PF stimulation alone, coactivation of PF and CF synapses greatly enhanced endocannabinoid-mediated inhibition of PF synapses. Retrograde inhibition was restricted to PFs activated within several hundred milliseconds of CF activation. This associative plasticity reflects two aspects of calcium-dependent endocannabinoid release. First, PF-mediated activation of metabotropic glutamate receptors locally reduced the dendritic calcium levels required for endocannabinoid release. Second, CFand PF coactivation evoked localized supralinear dendritic calcium signals. Thus, endocannabinoids mediate transient associative synaptic plasticity.
机译：联想学习在快速的时间尺度上很重要，但是还没有发现合适的形式的短期可塑性既是联想的又是突触的。在这里，我们评估内源性大麻素是否可以介导这种可塑性。在小脑中，平行纤维（PF）的爆发会引起内源性大麻素从Purkinje细胞树突中释放出来，导致持续数秒的逆行突触抑制。我们发现强大的攀岩纤维（CF）浦肯野细胞突触调节这种抑制作用。与单独的PF刺激相比，PF和CF突触的共激活大大增强了内源性大麻素介导的PF突触的抑制作用。逆行抑制仅限于CF激活数百毫秒内激活的PF。这种可塑性反映了钙依赖性内源性大麻素释放的两个方面。首先，PF介导的代谢型谷氨酸受体的激活会局部降低内源性大麻素释放所需的树突钙水平。其次，CF和PF共激活引起局部超线性树突状钙信号。因此，内源性大麻素介导短暂的联想突触可塑性。

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