...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >A preformed complex of postsynaptic proteins is involved in excitatory synapse development.
【24h】

A preformed complex of postsynaptic proteins is involved in excitatory synapse development.

机译：突触后蛋白的预制复合物参与兴奋性突触的发展。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nonsynaptic clusters of postsynaptic proteins have been documented; however, their role remains elusive. We monitored the trafficking of several candidate proteins implicated in synaptogenesis, when nonsynaptic clusters of scaffold proteins are most abundant. We find a protein complex consisting of two populations that differ in their content, mobility, and involvement in synapse formation. One subpopulation is mobile and relies on actin transport for delivery to nascent and existing synapses. These mobile clusters contain the scaffolding proteins PSD-95, GKAP, and Shank. A proportion of mobile clusters that exhibits slow movement and travels short distances contains neuroligin-1. The second group consists of stationary nonsynaptic scaffold complexes that mainly contain neuroligin-1, can recruit synaptophysin-containing axonal transport vesicles, and are readily transformed to functional presynaptic contacts that recycle the vital dye FM 4-64. These results postulate a mechanism whereby preformed scaffold protein complexes serve as predetermined postsynaptic hotspots for establishment of new functional excitatory synapses.
机译：突触后蛋白的非突触簇已被记录;但是，它们的作用仍然难以捉摸。当支架蛋白的非突触簇最丰富时，我们监测了涉及突触发生的几种候选蛋白的运输。我们发现蛋白质复合物由两个种群组成，这两个种群的内容，流动性和突触形成均不同。一个亚群是可移动的，并依赖肌动蛋白转运传递至新生和现有的突触。这些移动簇包含支架蛋白PSD-95，GKAP和Shank。表现出缓慢的运动和短距离移动的一部分移动簇包含Neuroligin-1。第二组由固定的非突触支架复合物组成，这些复合物主要包含Neuroligin-1，可以募集含有突触素的轴突转运囊泡，并易于转化为功能性突触前接触，从而回收重要染料FM 4-64。这些结果提出了一种机制，其中预先形成的支架蛋白复合物充当预定的突触后热点，用于建立新的功能性兴奋性突触。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号